View in EDS

Lirafugratinib attenuates ABCG2-dependent drug efflux and restores chemosensitivity in multidrug-resistant nonsmall cell lung cancer cells.

Saved in:
Bibliographic Details
Title: Lirafugratinib attenuates ABCG2-dependent drug efflux and restores chemosensitivity in multidrug-resistant nonsmall cell lung cancer cells.
Authors: Wu CP; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei 10507, Taiwan. Electronic address: wuchung@mail.cgu.edu.tw., Li YC; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan., Lin BH; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan., Murakami M; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA., Chang YT; Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan., Wu YS; Department of Chemistry, Tunghai University, Taichung 40704, Taiwan., Hung TH; Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei 10507, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Department of Obstetrics and Gynecology, Keelung Chang Gung Memorial Hospital, Keelung 20401, Taiwan. Electronic address: thh20@adm.cgmh.org.tw., Ambudkar SV; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Electronic address: ambudkar@mail.nih.gov.
Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2026 Apr; Vol. 54 (4), pp. 100258. Date of Electronic Publication: 2026 Feb 21.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41831281
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Lirafugratinib attenuates ABCG2-dependent drug efflux and restores chemosensitivity in multidrug-resistant nonsmall cell lung cancer cells.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Wu+CP%22">Wu CP</searchLink>; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei 10507, Taiwan. Electronic address: wuchung@mail.cgu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Li+YC%22">Li YC</searchLink>; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+BH%22">Lin BH</searchLink>; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Murakami+M%22">Murakami M</searchLink>; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.<br /><searchLink fieldCode="AU" term="%22Chang+YT%22">Chang YT</searchLink>; Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+YS%22">Wu YS</searchLink>; Department of Chemistry, Tunghai University, Taichung 40704, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+TH%22">Hung TH</searchLink>; Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei 10507, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Department of Obstetrics and Gynecology, Keelung Chang Gung Memorial Hospital, Keelung 20401, Taiwan. Electronic address: thh20@adm.cgmh.org.tw.<br /><searchLink fieldCode="AU" term="%22Ambudkar+SV%22">Ambudkar SV</searchLink>; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Electronic address: ambudkar@mail.nih.gov.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229421550%22">Drug metabolism and disposition: the biological fate of chemicals</searchLink> [Drug Metab Dispos] 2026 Apr; Vol. 54 (4), pp. 100258. <i>Date of Electronic Publication: </i>2026 Feb 21.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Pharmacology+and+Experimental+Therapeutics%2C+etc%2E]%22">American Society for Pharmacology and Experimental Therapeutics, etc.] </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9421550 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1521-009X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200909556%22">00909556 </searchLink><i>NLM ISO Abbreviation: </i>Drug Metab Dispos <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41831281
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.dmd.2026.100258
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 100258
    Titles:
      – TitleFull: Lirafugratinib attenuates ABCG2-dependent drug efflux and restores chemosensitivity in multidrug-resistant nonsmall cell lung cancer cells.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Wu CP
      – PersonEntity:
          Name:
            NameFull: Li YC
      – PersonEntity:
          Name:
            NameFull: Lin BH
      – PersonEntity:
          Name:
            NameFull: Murakami M
      – PersonEntity:
          Name:
            NameFull: Chang YT
      – PersonEntity:
          Name:
            NameFull: Wu YS
      – PersonEntity:
          Name:
            NameFull: Hung TH
      – PersonEntity:
          Name:
            NameFull: Ambudkar SV
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: 2026 Apr
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1521-009X
          Numbering:
            – Type: volume
              Value: 54
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Drug metabolism and disposition: the biological fate of chemicals
              Type: main
ResultId 1