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Artificial Intelligence-powered tiered early warning framework addressing high false alarm rates for in-hospital mortality prediction.

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Title: Artificial Intelligence-powered tiered early warning framework addressing high false alarm rates for in-hospital mortality prediction.
Authors: Wu L; Department of Emergency Medicine, Institute of Sciences in Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Mai L; Department of Emergency Medicine, Institute of Sciences in Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Wang H; Key Laboratory of Digital-Intelligent Disease Surveillance and Health Governance, North Sichuan Medical College, Nanchong, China., Huang J; Department of Emergency Medicine, Institute of Sciences in Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., He X; Department of Emergency Medicine, Institute of Sciences in Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Zhan X; Department of Emergency Medicine, Institute of Sciences in Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Khalemsky A; Jerusalem Multidisciplinary Academic Center, Jerusalem, Israel., Kumar VA; Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA., Paxton JH; Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA., Tsilimingras D; Department of Family Medicine & Public Health Sciences, Wayne State University School of Medicine, Detroit, MI, USA., Hachimi-Idrissi S; Department of Emergency Medicine, Ghent University Hospital, Ghent, Belgium; Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium; Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium., Liu SW; Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Savioli G; MD UOC Pronto Soccorso-Accettazione Fondazione IRCCS San Matteo Dipartimento Medicina Intensiva Università degli Studi di Pavia, Pavia, Italy., Rathlev NK; Department of Emergency Medicine, University of Massachusetts Medical School, Baystate, Springfield, MA, USA., Tazarourte K; Department of Health Quality, University Hospital, Hospices Civils, Lyon, France.; Department of Emergency Medicine, University Hospital, Hospices Civils, Lyon, France., Slagman A; Division of Emergency and Acute Medicine, Campus Virchow Klinikum and Charité Campus Mitte, Charité Universitätsmedizin, Berlin, Germany., Christ M; Department of Emergency Medicine, Lucerne, Switzerland., Qureshi M; King Faisal Specialist Hospital and Research Center, College of Medicine, Alfaisal university, Ryadh, Kingdom of Saudi Arabia., Hariri H; King Faisal Specialist Hospital and Research Center, College of Medicine, Alfaisal university, Ryadh, Kingdom of Saudi Arabia., Grossman SA; Department of Emergency of Medicine, Beth Israel Deaconess Medical Center, Teaching Hospital of Harvard Medical School, Boston, MA, USA., Hu B; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China., Wang H; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China., He B; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China., Levy PD; Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA., O'Neil BJ; Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA., Gemme S; Department of Emergency Medicine, University of Massachusetts Medical School, Baystate, Springfield, MA, USA., Kurland L; Department of Medical Sciences, Örebro University, Örebro, Sweden., Lang E; Department of Emergency Medicine, Emergency Medicine Cumming School of Medicine, University of Calgary, Alberta Health Services, Calgary, Canada., Lin J; Department of Emergency Medicine, People's Hospital of Shenzhen Baoan District, The Second Affiliated Hospital of Shenzhen University, Shenzhen, China. lljjll2010@126.com., Liang H; Medical Big Data Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. lianghuiying@gdph.org.cn., Li X; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China. sylixin@scut.edu.cn., Bellou A; Department of Emergency Medicine, Institute of Sciences in Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. abellou402@gmail.com.; Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA. abellou402@gmail.com.; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China. abellou402@gmail.com.; Global Network on Emergency Medicine, Brookline, MA, USA. abellou402@gmail.com.
Source: NPJ digital medicine [NPJ Digit Med] 2026 Mar 14; Vol. 9 (1). Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101731738 Publication Model: Electronic Cited Medium: Internet ISSN: 2398-6352 (Electronic) Linking ISSN: 23986352 NLM ISO Abbreviation: NPJ Digit Med Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Artificial Intelligence-powered tiered early warning framework addressing high false alarm rates for in-hospital mortality prediction.
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  Data: <searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; Department of Emergency Medicine, Institute of Sciences in Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Mai+L%22">Mai L</searchLink>; Department of Emergency Medicine, Institute of Sciences in Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Key Laboratory of Digital-Intelligent Disease Surveillance and Health Governance, North Sichuan Medical College, Nanchong, China.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Emergency Medicine, Institute of Sciences in Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22He+X%22">He X</searchLink>; Department of Emergency Medicine, Institute of Sciences in Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhan+X%22">Zhan X</searchLink>; Department of Emergency Medicine, Institute of Sciences in Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Khalemsky+A%22">Khalemsky A</searchLink>; Jerusalem Multidisciplinary Academic Center, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Kumar+VA%22">Kumar VA</searchLink>; Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Paxton+JH%22">Paxton JH</searchLink>; Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Tsilimingras+D%22">Tsilimingras D</searchLink>; 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Department of Health Quality, University Hospital, Hospices Civils, Lyon, France.; Department of Emergency Medicine, University Hospital, Hospices Civils, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Slagman+A%22">Slagman A</searchLink>; Division of Emergency and Acute Medicine, Campus Virchow Klinikum and Charité Campus Mitte, Charité Universitätsmedizin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Christ+M%22">Christ M</searchLink>; Department of Emergency Medicine, Lucerne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Qureshi+M%22">Qureshi M</searchLink>; King Faisal Specialist Hospital and Research Center, College of Medicine, Alfaisal university, Ryadh, Kingdom of Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Hariri+H%22">Hariri H</searchLink>; King Faisal Specialist Hospital and Research Center, College of Medicine, Alfaisal university, Ryadh, Kingdom of Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Grossman+SA%22">Grossman SA</searchLink>; Department of Emergency of Medicine, Beth Israel Deaconess Medical Center, Teaching Hospital of Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hu+B%22">Hu B</searchLink>; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22He+B%22">He B</searchLink>; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Levy+PD%22">Levy PD</searchLink>; Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22O'Neil+BJ%22">O'Neil BJ</searchLink>; Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Gemme+S%22">Gemme S</searchLink>; Department of Emergency Medicine, University of Massachusetts Medical School, Baystate, Springfield, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kurland+L%22">Kurland L</searchLink>; Department of Medical Sciences, Örebro University, Örebro, Sweden.<br /><searchLink fieldCode="AU" term="%22Lang+E%22">Lang E</searchLink>; Department of Emergency Medicine, Emergency Medicine Cumming School of Medicine, University of Calgary, Alberta Health Services, Calgary, Canada.<br /><searchLink fieldCode="AU" term="%22Lin+J%22">Lin J</searchLink>; Department of Emergency Medicine, People's Hospital of Shenzhen Baoan District, The Second Affiliated Hospital of Shenzhen University, Shenzhen, China. lljjll2010@126.com.<br /><searchLink fieldCode="AU" term="%22Liang+H%22">Liang H</searchLink>; Medical Big Data Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. lianghuiying@gdph.org.cn.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China. sylixin@scut.edu.cn.<br /><searchLink fieldCode="AU" term="%22Bellou+A%22">Bellou A</searchLink>; Department of Emergency Medicine, Institute of Sciences in Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. abellou402@gmail.com.; Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA. abellou402@gmail.com.; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China. abellou402@gmail.com.; Global Network on Emergency Medicine, Brookline, MA, USA. abellou402@gmail.com.
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