Disrupting Akt-Wnt/β-catenin signaling suppresses glioblastoma stem cell growth and tumor progression in immunocompetent mice.

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Title: Disrupting Akt-Wnt/β-catenin signaling suppresses glioblastoma stem cell growth and tumor progression in immunocompetent mice.
Authors: Sarkar MM; Regenerative Bioscience Center, Edgar L. Rhodes Center for Animal and Dairy Science, University of Georgia, Athens, GA, USA.; College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, USA.; Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA., Gonsalves N; Regenerative Bioscience Center, Edgar L. Rhodes Center for Animal and Dairy Science, University of Georgia, Athens, GA, USA.; College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, USA.; Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA., Davarzani A; Regenerative Bioscience Center, Edgar L. Rhodes Center for Animal and Dairy Science, University of Georgia, Athens, GA, USA.; School of Electrical and Computer Engineering, College of Engineering, University of Georgia, Athens, GA, USA., Mitchell E; Regenerative Bioscience Center, Edgar L. Rhodes Center for Animal and Dairy Science, University of Georgia, Athens, GA, USA.; Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA., Singh AM; Regenerative Bioscience Center, Edgar L. Rhodes Center for Animal and Dairy Science, University of Georgia, Athens, GA, USA.; College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, USA.; Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA., Karumbaiah L; Regenerative Bioscience Center, Edgar L. Rhodes Center for Animal and Dairy Science, University of Georgia, Athens, GA, USA. lohitash@uga.edu.; College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, USA. lohitash@uga.edu.; Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA. lohitash@uga.edu., Stice SL; Regenerative Bioscience Center, Edgar L. Rhodes Center for Animal and Dairy Science, University of Georgia, Athens, GA, USA. sstice@uga.edu.; College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, USA. sstice@uga.edu.; Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA. sstice@uga.edu.
Source: Journal of neuro-oncology [J Neurooncol] 2026 Mar 14; Vol. 177 (1). Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1573-7373
DOI:10.1007/s11060-026-05428-3