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The P2X4 purinergic receptor controls the autophagy-related release of small extracellular vesicles from mammary cancer cells under hypoxia.

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Title: The P2X4 purinergic receptor controls the autophagy-related release of small extracellular vesicles from mammary cancer cells under hypoxia.
Authors: Duret T; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France., Elmallah M; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France., Heraud-Meley A; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France., Tessier C; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France., Da Silva AVV; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France., Chadet S; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France., Lemoine R; Plateforme ASB, Cytometry and Single cell Immunobiology, Université de Tours, CHU Tours, Inserm US61, Tours, France., Gainche J; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France., Labas V; INRAE, CNRS, Université de Tours, UMR PRC, Nouzilly, France.; INRAE, Université de Tours, CHU de Tours, PIXANIM, Nouzilly, France., Teixeira-Gomes AP; INRAE, CNRS, Université de Tours, UMR PRC, Nouzilly, France.; INRAE, Université de Tours, CHU de Tours, PIXANIM, Nouzilly, France., Tomas D; INRAE, CNRS, Université de Tours, UMR PRC, Nouzilly, France.; INRAE, Université de Tours, CHU de Tours, PIXANIM, Nouzilly, France., Cuplov V; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France., Jiang LH; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.; Henan Medical University, Xinxiang, Henan province, China.; School of Biomedical Sciences, University of Leeds, Leeds, UK., Fan L; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.; Central South University, Changsha, Hunan Province, China., Yin G; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.; Central South University, Changsha, Hunan Province, China., Baron C; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.; Service de Néphrologie, Dialyse et Transplantation Rénale, CHRU Tours, Tours, France.; Fédération Hospitalo-Universitaire Survival Optimization in Organ Transplantation (FHU SUPORT), Tours, France., Roger S; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France. sebastien.roger@univ-tours.fr.; Fédération Hospitalo-Universitaire Survival Optimization in Organ Transplantation (FHU SUPORT), Tours, France. sebastien.roger@univ-tours.fr.
Source: Cell communication and signaling : CCS [Cell Commun Signal] 2026 Mar 14; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The P2X4 purinergic receptor controls the autophagy-related release of small extracellular vesicles from mammary cancer cells under hypoxia.
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  Data: <searchLink fieldCode="AU" term="%22Duret+T%22">Duret T</searchLink>; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.<br /><searchLink fieldCode="AU" term="%22Elmallah+M%22">Elmallah M</searchLink>; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.<br /><searchLink fieldCode="AU" term="%22Heraud-Meley+A%22">Heraud-Meley A</searchLink>; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.<br /><searchLink fieldCode="AU" term="%22Tessier+C%22">Tessier C</searchLink>; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.<br /><searchLink fieldCode="AU" term="%22Da+Silva+AVV%22">Da Silva AVV</searchLink>; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.<br /><searchLink fieldCode="AU" term="%22Chadet+S%22">Chadet S</searchLink>; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.<br /><searchLink fieldCode="AU" term="%22Lemoine+R%22">Lemoine R</searchLink>; Plateforme ASB, Cytometry and Single cell Immunobiology, Université de Tours, CHU Tours, Inserm US61, Tours, France.<br /><searchLink fieldCode="AU" term="%22Gainche+J%22">Gainche J</searchLink>; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.<br /><searchLink fieldCode="AU" term="%22Labas+V%22">Labas V</searchLink>; INRAE, CNRS, Université de Tours, UMR PRC, Nouzilly, France.; INRAE, Université de Tours, CHU de Tours, PIXANIM, Nouzilly, France.<br /><searchLink fieldCode="AU" term="%22Teixeira-Gomes+AP%22">Teixeira-Gomes AP</searchLink>; INRAE, CNRS, Université de Tours, UMR PRC, Nouzilly, France.; INRAE, Université de Tours, CHU de Tours, PIXANIM, Nouzilly, France.<br /><searchLink fieldCode="AU" term="%22Tomas+D%22">Tomas D</searchLink>; INRAE, CNRS, Université de Tours, UMR PRC, Nouzilly, France.; INRAE, Université de Tours, CHU de Tours, PIXANIM, Nouzilly, France.<br /><searchLink fieldCode="AU" term="%22Cuplov+V%22">Cuplov V</searchLink>; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.<br /><searchLink fieldCode="AU" term="%22Jiang+LH%22">Jiang LH</searchLink>; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.; Henan Medical University, Xinxiang, Henan province, China.; School of Biomedical Sciences, University of Leeds, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Fan+L%22">Fan L</searchLink>; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.; Central South University, Changsha, Hunan Province, China.<br /><searchLink fieldCode="AU" term="%22Yin+G%22">Yin G</searchLink>; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.; Central South University, Changsha, Hunan Province, China.<br /><searchLink fieldCode="AU" term="%22Baron+C%22">Baron C</searchLink>; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France.; Service de Néphrologie, Dialyse et Transplantation Rénale, CHRU Tours, Tours, France.; Fédération Hospitalo-Universitaire Survival Optimization in Organ Transplantation (FHU SUPORT), Tours, France.<br /><searchLink fieldCode="AU" term="%22Roger+S%22">Roger S</searchLink>; Université de Tours, Inserm UMR1327 ISCHEMIA, Membrane Signalling and Inflammation in Reperfusion Injuries, 10 Boulevard Tonnellé, Tours, 37032, France. sebastien.roger@univ-tours.fr.; Fédération Hospitalo-Universitaire Survival Optimization in Organ Transplantation (FHU SUPORT), Tours, France. sebastien.roger@univ-tours.fr.
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