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Surface-water estradiol-benzo[a]pyrene mixtures: Transcriptomics in a PC12 neuronal differentiation model nominate an E2F1-PTPRO axis as a candidate mechanistic biomarker.

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Title: Surface-water estradiol-benzo[a]pyrene mixtures: Transcriptomics in a PC12 neuronal differentiation model nominate an E2F1-PTPRO axis as a candidate mechanistic biomarker.
Authors: Sun C; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China; School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom., Wang P; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China., Xia Y; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China., An M; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China., Liu S; Jilin Provincial Key Laboratory of Resource Utilization of Chemical Wastes, Jilin University of Chemical Technology, Jilin, China., Wu C; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China., Zhang W; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China., Li W; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China., Zhou Y; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China., Hao J; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China., Xu L; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China. Electronic address: xuliang@jluct.edu.cn.
Source: Toxicology letters [Toxicol Lett] 2026 May 01; Vol. 419, pp. 111882. Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Surface-water estradiol-benzo[a]pyrene mixtures: Transcriptomics in a PC12 neuronal differentiation model nominate an E2F1-PTPRO axis as a candidate mechanistic biomarker.
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  Data: <searchLink fieldCode="AU" term="%22Sun+C%22">Sun C</searchLink>; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China; School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China.<br /><searchLink fieldCode="AU" term="%22Xia+Y%22">Xia Y</searchLink>; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China.<br /><searchLink fieldCode="AU" term="%22An+M%22">An M</searchLink>; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Jilin Provincial Key Laboratory of Resource Utilization of Chemical Wastes, Jilin University of Chemical Technology, Jilin, China.<br /><searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China.<br /><searchLink fieldCode="AU" term="%22Hao+J%22">Hao J</searchLink>; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; Jilin University of Chemical Technology, No. 45 Chengde Street, Longtan District, Jilin, Jilin 132002, China. Electronic address: xuliang@jluct.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%227709027%22">Toxicology letters</searchLink> [Toxicol Lett] 2026 May 01; Vol. 419, pp. 111882. <i>Date of Electronic Publication: </i>2026 Mar 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>7709027 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-3169 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203784274%22">03784274 </searchLink><i>NLM ISO Abbreviation: </i>Toxicol Lett <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.toxlet.2026.111882
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      – TitleFull: Surface-water estradiol-benzo[a]pyrene mixtures: Transcriptomics in a PC12 neuronal differentiation model nominate an E2F1-PTPRO axis as a candidate mechanistic biomarker.
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              Text: 2026 May 01
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