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Altered frontal and occipital cortical microstructure in obsessive-compulsive disorder - a multisite mega-analysis.

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Title: Altered frontal and occipital cortical microstructure in obsessive-compulsive disorder - a multisite mega-analysis.
Authors: Thorsen AL; Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway. anders.lillevik.thorsen@helse-bergen.no.; Centre for Crisis Psychology, University of Bergen, Bergen, Norway. anders.lillevik.thorsen@helse-bergen.no.; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, De Boelelaan, 1117, Netherlands. anders.lillevik.thorsen@helse-bergen.no., Brecke V; Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.; Centre for Crisis Psychology, University of Bergen, Bergen, Norway., Alnæs D; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychology, Pedagogy and Law, Kristiania University College, Oslo, Norway., Mataix-Cols D; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.; Department of Clinical Sciences, Lund University, Lund, Sweden., Kwon JS; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea., Menchon JM; Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain., Abe Y; Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Sakai Y; Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.; Department of Neural Computation for Decision-Making, Advanced Telecommunications Research Institute International Brain Information Communication Research Laboratory Group, Kyoto, Japan., Phillips ML; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA., Hansen B; Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.; Centre for Crisis Psychology, University of Bergen, Bergen, Norway., Hoexter M; Institute of Psychiatry, Hospital das Clínicas, University of São Paulo, São Paulo, Brasil., Reddy J; Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India., Benedetti F; Department of Psychiatry and Clinical Psychobiology, Scientific Institute Ospedale, Milan, Italy., Brennan BP; McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA., Cheng Y; Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China., Denys D; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands.; Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands., Hirano Y; Research Center for Child Mental Development, Chiba University, Chiba, Japan., Koch K; Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.; TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München, Munich, Germany., Nakao T; Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Nurmi EL; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA., Simpson HB; Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; Center for OCD and Related Disorders, New York State Psychiatric Institute, New York, NY, USA., Piras F; Laboratory of Neuropsychiatry, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation, Rome, Italy., Tolin DF; Institute of Living/Hartford Hospital, Hartford, Connecticut, USA.; Yale University School of Medicine, New Haven, Connecticut, USA., Stern ER; Department of Psychiatry, New York University School of Medicine, New York, NY, USA.; Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA., Wang Z; Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, PR China., Buitelaar J; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.; Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands., Morgado P; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.; Clinical Academic Center-Braga, Braga, Portugal., Beucke JC; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.; Institute for Systems Medicine & Department of Human Medicine, MSH Medical School Hamburg, Hamburg, Germany., Lochner C; SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa., Stein DJ; SAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa., van den Heuvel OA; Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, De Boelelaan, 1117, Netherlands.; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, De Boelelaan 1117, Amsterdam, Netherlands.; Amsterdam Neuroscience, Compulsivity, Impulsivity and Attention program, Amsterdam, Netherlands., Ousdal OT; Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.; Department of Biomedicine, University of Bergen, Bergen, Norway.; Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Corporate Authors: ENIGMA-OCD Working Group, OCD Brain Imaging Consortium
Source: Molecular psychiatry [Mol Psychiatry] 2026 Jul; Vol. 31 (7), pp. 4074-4082. Date of Electronic Publication: 2026 Mar 15.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.; Department of Clinical Sciences, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Kwon+JS%22">Kwon JS</searchLink>; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Menchon+JM%22">Menchon JM</searchLink>; Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Abe+Y%22">Abe Y</searchLink>; Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Sakai+Y%22">Sakai Y</searchLink>; Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.; 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Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, De Boelelaan, 1117, Netherlands.; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, De Boelelaan 1117, Amsterdam, Netherlands.; Amsterdam Neuroscience, Compulsivity, Impulsivity and Attention program, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Ousdal+OT%22">Ousdal OT</searchLink>; Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.; Department of Biomedicine, University of Bergen, Bergen, Norway.; Department of Radiology, Haukeland University Hospital, Bergen, Norway.
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