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Pathogen characteristics are key determinants of distinct host response phenotypes of sepsis.

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Title: Pathogen characteristics are key determinants of distinct host response phenotypes of sepsis.
Authors: Chanderraj R; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Medicine Service, Infectious Diseases Section, Veterans Affairs (VA) Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.; Weil Institute for Critical Care Research & Innovation, Ann Arbor, Michigan, USA., Bartek B; Division of Clinical and Translational Research, Division of Critical Care, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA., Stringer KA; Weil Institute for Critical Care Research & Innovation, Ann Arbor, Michigan, USA.; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Department of Clinical Pharmacy, College of Pharmacy., Tiba MH; Weil Institute for Critical Care Research & Innovation, Ann Arbor, Michigan, USA.; Department of Emergency Medicine., Sjoding MW; Weil Institute for Critical Care Research & Innovation, Ann Arbor, Michigan, USA.; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA.; Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA., He Y; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Nuppnau M; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Bongers KS; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine, University of Iowa Medical School, Iowa City, Iowa, USA., Adame MD; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Lou SS; Division of Clinical and Translational Research, Division of Critical Care, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Anesthesiology and.; Institute for Informatics, Data Science, and Biostatistics, Washington University School of Medicine, St Louis, Missouri, USA., Kerschberger VE; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Churpek MM; Department of Medicine and.; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, USA., Calfee CS; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine.; Department of Anesthesiology.; Cardiovascular Research Institute, UCSF, San Francisco, California, USA., Tripathi S; Division of Clinical and Translational Research, Division of Critical Care, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA., Foster DM; Spectral Medical Inc., Toronto, Ontario, Canada., Kellum JA; Spectral Medical Inc., Toronto, Ontario, Canada.; Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Dickson RP; Weil Institute for Critical Care Research & Innovation, Ann Arbor, Michigan, USA.; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Sinha P; Division of Clinical and Translational Research, Division of Critical Care, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2026 Mar 16; Vol. 136 (6). Date of Electronic Publication: 2026 Mar 16 (Print Publication: 2026).
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pathogen characteristics are key determinants of distinct host response phenotypes of sepsis.
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  Data: <searchLink fieldCode="AU" term="%22Chanderraj+R%22">Chanderraj R</searchLink>; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Medicine Service, Infectious Diseases Section, Veterans Affairs (VA) Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.; Weil Institute for Critical Care Research & Innovation, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Bartek+B%22">Bartek B</searchLink>; Division of Clinical and Translational Research, Division of Critical Care, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Stringer+KA%22">Stringer KA</searchLink>; Weil Institute for Critical Care Research & Innovation, Ann Arbor, Michigan, USA.; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Department of Clinical Pharmacy, College of Pharmacy.<br /><searchLink fieldCode="AU" term="%22Tiba+MH%22">Tiba MH</searchLink>; Weil Institute for Critical Care Research & Innovation, Ann Arbor, Michigan, USA.; Department of Emergency Medicine.<br /><searchLink fieldCode="AU" term="%22Sjoding+MW%22">Sjoding MW</searchLink>; Weil Institute for Critical Care Research & Innovation, Ann Arbor, Michigan, USA.; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA.; Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Nuppnau+M%22">Nuppnau M</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Bongers+KS%22">Bongers KS</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine, University of Iowa Medical School, Iowa City, Iowa, USA.<br /><searchLink fieldCode="AU" term="%22Adame+MD%22">Adame MD</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Lou+SS%22">Lou SS</searchLink>; Division of Clinical and Translational Research, Division of Critical Care, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Anesthesiology and.; Institute for Informatics, Data Science, and Biostatistics, Washington University School of Medicine, St Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Kerschberger+VE%22">Kerschberger VE</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Churpek+MM%22">Churpek MM</searchLink>; Department of Medicine and.; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Calfee+CS%22">Calfee CS</searchLink>; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine.; Department of Anesthesiology.; Cardiovascular Research Institute, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Tripathi+S%22">Tripathi S</searchLink>; Division of Clinical and Translational Research, Division of Critical Care, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Foster+DM%22">Foster DM</searchLink>; Spectral Medical Inc., Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kellum+JA%22">Kellum JA</searchLink>; Spectral Medical Inc., Toronto, Ontario, Canada.; Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Dickson+RP%22">Dickson RP</searchLink>; Weil Institute for Critical Care Research & Innovation, Ann Arbor, Michigan, USA.; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Sinha+P%22">Sinha P</searchLink>; Division of Clinical and Translational Research, Division of Critical Care, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA.
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  Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2026 Mar 16; Vol. 136 (6). <i>Date of Electronic Publication: </i>2026 Mar 16 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802877 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1558-8238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219738%22">00219738 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Invest <i>Subsets: </i>MEDLINE
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        Value: 10.1172/JCI197346
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              Text: 2026 Mar 16
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