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Tocilizumab Efficacy Across Inflammatory Subphenotypes in COVID-19-Related Acute Respiratory Distress Syndrome.

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Title: Tocilizumab Efficacy Across Inflammatory Subphenotypes in COVID-19-Related Acute Respiratory Distress Syndrome.
Authors: Filippini DFL; Department of Intensive Care Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Khyali J; Department of Intensive Care Medicine, Erasmus MC, Erasmus University Rotterdam, Rotterdam, The Netherlands., Janssen M; Department of Intensive Care Medicine, Erasmus MC, Erasmus University Rotterdam, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, Erasmus University Rotterdam, Rotterdam, The Netherlands., Rademaker E; Department of Intensive Care Medicine, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands., Cremer OL; Department of Intensive Care Medicine, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands., van der Poll T; Center for Infection and Molecular Medicine (C.I.M.M.), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Division of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., van Amstel RBE; Department of Intensive Care Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Endeman H; Department of Intensive Care Medicine, Erasmus MC, Erasmus University Rotterdam, Rotterdam, The Netherlands.; Department of Intensive Care Medicine, OLVG, Amsterdam, The Netherlands., Bos LDJ; Department of Intensive Care Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of Pulmonology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), University of Amsterdam, Amsterdam, The Netherlands.
Corporate Authors: Amsterdam UMC COVID-19 Biobank Study Group
Source: Critical care explorations [Crit Care Explor] 2026 Mar 16; Vol. 8 (3), pp. e1392. Date of Electronic Publication: 2026 Mar 16 (Print Publication: 2026).
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 101746347 Publication Model: eCollection Cited Medium: Internet ISSN: 2639-8028 (Electronic) Linking ISSN: 26398028 NLM ISO Abbreviation: Crit Care Explor Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tocilizumab Efficacy Across Inflammatory Subphenotypes in COVID-19-Related Acute Respiratory Distress Syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Filippini+DFL%22">Filippini DFL</searchLink>; Department of Intensive Care Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Khyali+J%22">Khyali J</searchLink>; Department of Intensive Care Medicine, Erasmus MC, Erasmus University Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Janssen+M%22">Janssen M</searchLink>; Department of Intensive Care Medicine, Erasmus MC, Erasmus University Rotterdam, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, Erasmus University Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rademaker+E%22">Rademaker E</searchLink>; Department of Intensive Care Medicine, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Cremer+OL%22">Cremer OL</searchLink>; Department of Intensive Care Medicine, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Poll+T%22">van der Poll T</searchLink>; Center for Infection and Molecular Medicine (C.I.M.M.), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Division of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Amstel+RBE%22">van Amstel RBE</searchLink>; Department of Intensive Care Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Endeman+H%22">Endeman H</searchLink>; Department of Intensive Care Medicine, Erasmus MC, Erasmus University Rotterdam, Rotterdam, The Netherlands.; Department of Intensive Care Medicine, OLVG, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bos+LDJ%22">Bos LDJ</searchLink>; Department of Intensive Care Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of Pulmonology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), University of Amsterdam, Amsterdam, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101746347%22">Critical care explorations</searchLink> [Crit Care Explor] 2026 Mar 16; Vol. 8 (3), pp. e1392. <i>Date of Electronic Publication: </i>2026 Mar 16 (<i>Print Publication: </i>2026).
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              Text: 2026 Mar 16
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