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Next-generation broad-spectrum reactivators for effective countermeasure against organophosphorus poisoning.

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Title: Next-generation broad-spectrum reactivators for effective countermeasure against organophosphorus poisoning.
Authors: Zdarova Karasova J; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic. jana.zdarovakarasova@unob.cz., Hrabinova M; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Dlabkova A; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Hepnarova V; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Zivna N; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic., Schmidt M; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic., Sheshko V; Department of Molecular Pathology and Biology, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Torruellas C; U. S. Army CCDC Chemical Biological Center, Aberdeen Proving Ground, MD, 21010-5424, USA., Opravil J; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Prchal L; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic., Vanova N; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Fibigar J; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Vecera Z; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Kucera T; Department of Military Medical Service Organization and Management, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Chladek J; Department of Pharmacology, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03, Hradec Kralove, Czech Republic., Horn G; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany., Worek F; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany., Marek J; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.; Department of Epidemiology, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Pejchal J; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Jun D; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic., Soukup O; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic., Korabecny J; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic., Gorecki L; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic. lukasgorecki@seznam.cz.; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic. lukasgorecki@seznam.cz.
Source: Archives of toxicology [Arch Toxicol] 2026 Jun; Vol. 100 (6), pp. 2467-2502. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Next-generation broad-spectrum reactivators for effective countermeasure against organophosphorus poisoning.
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  Data: <searchLink fieldCode="AU" term="%22Zdarova+Karasova+J%22">Zdarova Karasova J</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic. jana.zdarovakarasova@unob.cz.<br /><searchLink fieldCode="AU" term="%22Hrabinova+M%22">Hrabinova M</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Dlabkova+A%22">Dlabkova A</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Hepnarova+V%22">Hepnarova V</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Zivna+N%22">Zivna N</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Schmidt+M%22">Schmidt M</searchLink>; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Sheshko+V%22">Sheshko V</searchLink>; Department of Molecular Pathology and Biology, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Torruellas+C%22">Torruellas C</searchLink>; U. 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Army CCDC Chemical Biological Center, Aberdeen Proving Ground, MD, 21010-5424, USA.<br /><searchLink fieldCode="AU" term="%22Opravil+J%22">Opravil J</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Prchal+L%22">Prchal L</searchLink>; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Vanova+N%22">Vanova N</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Fibigar+J%22">Fibigar J</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Vecera+Z%22">Vecera Z</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kucera+T%22">Kucera T</searchLink>; Department of Military Medical Service Organization and Management, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Chladek+J%22">Chladek J</searchLink>; Department of Pharmacology, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Horn+G%22">Horn G</searchLink>; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Worek+F%22">Worek F</searchLink>; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Marek+J%22">Marek J</searchLink>; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.; Department of Epidemiology, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Pejchal+J%22">Pejchal J</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Jun+D%22">Jun D</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Soukup+O%22">Soukup O</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Korabecny+J%22">Korabecny J</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Gorecki+L%22">Gorecki L</searchLink>; Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic. lukasgorecki@seznam.cz.; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic. lukasgorecki@seznam.cz.
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  Data: <searchLink fieldCode="JN" term="%220417615%22">Archives of toxicology</searchLink> [Arch Toxicol] 2026 Jun; Vol. 100 (6), pp. 2467-2502. <i>Date of Electronic Publication: </i>2026 Mar 16.
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