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Limonene and carvacrol combined with drugs that inhibit ergosterol synthesis are potent against Leishmania major.

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Title: Limonene and carvacrol combined with drugs that inhibit ergosterol synthesis are potent against Leishmania major.
Authors: de Carvalho RCV; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil., Dos Reis Bacelar KG; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil., Pereira EL; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil., Dos Anjos BS; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil., Melo ECS; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil., de Souza Cunha FDC; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil.; Graduate Program in Technologies Applied to Animals of Regional Interest, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil., de Araujo Sousa PS; Medicinal Chemistry and Biotechnology Research Group, QUIMEBIO, Federal University of Maranhão, UFMA, São Bernardo, Maranhão, MA, Brazil., Rocha JA; Medicinal Chemistry and Biotechnology Research Group, QUIMEBIO, Federal University of Maranhão, UFMA, São Bernardo, Maranhão, MA, Brazil., Véras LMC; CCB (Bacabal Science Center), Federal University of Maranhão (UFMA), Bacabal Campus, BacabalMaranhão, 65700-000, Brazil., da Franca Rodrigues KA; CEBSI (Special Coordination of Biological and Health Sciences), Federal University of Maranhão, São LuísMaranhão, 65080805, Brazil., de Freire Medeiros MDG; Department of Pharmacy, Federal University of Piaui, TeresinaPiauí, 64049-550, Brazil., Arcanjo DDR; Department of Biophysics and Physiology, Federal University of Piaui, TeresinaPiauí, 64049-550, Brazil., Alves MMM; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil. mualemmichel@ufpi.edu.br.; Graduate Program in Technologies Applied to Animals of Regional Interest, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil. mualemmichel@ufpi.edu.br.; Department of Veterinary Morphophysiology, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, PI, 64049-550, Brazil. mualemmichel@ufpi.edu.br., Carvalho FAA; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil.; Department of Biochemistry and Pharmacology, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 May; Vol. 399 (8), pp. 12599-12612. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
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  Data: Limonene and carvacrol combined with drugs that inhibit ergosterol synthesis are potent against Leishmania major.
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  Data: <searchLink fieldCode="AU" term="%22de+Carvalho+RCV%22">de Carvalho RCV</searchLink>; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Reis+Bacelar+KG%22">Dos Reis Bacelar KG</searchLink>; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil.<br /><searchLink fieldCode="AU" term="%22Pereira+EL%22">Pereira EL</searchLink>; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Anjos+BS%22">Dos Anjos BS</searchLink>; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil.<br /><searchLink fieldCode="AU" term="%22Melo+ECS%22">Melo ECS</searchLink>; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Souza+Cunha+FDC%22">de Souza Cunha FDC</searchLink>; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil.; Graduate Program in Technologies Applied to Animals of Regional Interest, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Araujo+Sousa+PS%22">de Araujo Sousa PS</searchLink>; Medicinal Chemistry and Biotechnology Research Group, QUIMEBIO, Federal University of Maranhão, UFMA, São Bernardo, Maranhão, MA, Brazil.<br /><searchLink fieldCode="AU" term="%22Rocha+JA%22">Rocha JA</searchLink>; Medicinal Chemistry and Biotechnology Research Group, QUIMEBIO, Federal University of Maranhão, UFMA, São Bernardo, Maranhão, MA, Brazil.<br /><searchLink fieldCode="AU" term="%22Véras+LMC%22">Véras LMC</searchLink>; CCB (Bacabal Science Center), Federal University of Maranhão (UFMA), Bacabal Campus, BacabalMaranhão, 65700-000, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Franca+Rodrigues+KA%22">da Franca Rodrigues KA</searchLink>; CEBSI (Special Coordination of Biological and Health Sciences), Federal University of Maranhão, São LuísMaranhão, 65080805, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Freire+Medeiros+MDG%22">de Freire Medeiros MDG</searchLink>; Department of Pharmacy, Federal University of Piaui, TeresinaPiauí, 64049-550, Brazil.<br /><searchLink fieldCode="AU" term="%22Arcanjo+DDR%22">Arcanjo DDR</searchLink>; Department of Biophysics and Physiology, Federal University of Piaui, TeresinaPiauí, 64049-550, Brazil.<br /><searchLink fieldCode="AU" term="%22Alves+MMM%22">Alves MMM</searchLink>; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil. mualemmichel@ufpi.edu.br.; Graduate Program in Technologies Applied to Animals of Regional Interest, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil. mualemmichel@ufpi.edu.br.; Department of Veterinary Morphophysiology, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, PI, 64049-550, Brazil. mualemmichel@ufpi.edu.br.<br /><searchLink fieldCode="AU" term="%22Carvalho+FAA%22">Carvalho FAA</searchLink>; BioLeish (Advanced Research in Leishmania and Alternative Models), Medicinal Plants Research Center, Campus Ministro Petrônio Portella, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil.; Department of Biochemistry and Pharmacology, Federal University of Piauí, TeresinaPiauí, 64049-550, Brazil.
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  Data: <searchLink fieldCode="JN" term="%220326264%22">Naunyn-Schmiedeberg's archives of pharmacology</searchLink> [Naunyn Schmiedebergs Arch Pharmacol] 2026 May; Vol. 399 (8), pp. 12599-12612. <i>Date of Electronic Publication: </i>2026 Mar 16.
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