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High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin.

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Title: High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin.
Authors: Fanti R; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada., Wolf E; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada., Ikenoue T; Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan., Deme JC; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702., Balakrishnan S; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada., Keith BA; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada., Alteen MG; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada., Chandrasekaran R; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada., Yadav M; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G1L7, Canada., Bhajiawala R; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada., Ackloo S; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada., Feng J; Department of Medical Genetics, Vancouver, BC V5Z 4H4, Canada.; Centre for Molecular Medicine and Therapeutics, Vancouver, BC V5Z 4H4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Edwin S.H Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada., Pouladi MA; Department of Medical Genetics, Vancouver, BC V5Z 4H4, Canada.; Centre for Molecular Medicine and Therapeutics, Vancouver, BC V5Z 4H4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Edwin S.H Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada., Edwards AM; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada., Wilson DJ; Department of Chemistry, York University, Toronto, ON M3J 1P3, Canada., Lea SM; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702., Suga H; Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan., Harding RJ; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 24; Vol. 123 (12), pp. e2520462123. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Fanti+R%22">Fanti R</searchLink>; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Wolf+E%22">Wolf E</searchLink>; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.<br /><searchLink fieldCode="AU" term="%22Ikenoue+T%22">Ikenoue T</searchLink>; Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.<br /><searchLink fieldCode="AU" term="%22Deme+JC%22">Deme JC</searchLink>; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.<br /><searchLink fieldCode="AU" term="%22Balakrishnan+S%22">Balakrishnan S</searchLink>; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Keith+BA%22">Keith BA</searchLink>; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Alteen+MG%22">Alteen MG</searchLink>; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Chandrasekaran+R%22">Chandrasekaran R</searchLink>; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Yadav+M%22">Yadav M</searchLink>; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Bhajiawala+R%22">Bhajiawala R</searchLink>; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Ackloo+S%22">Ackloo S</searchLink>; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Feng+J%22">Feng J</searchLink>; Department of Medical Genetics, Vancouver, BC V5Z 4H4, Canada.; Centre for Molecular Medicine and Therapeutics, Vancouver, BC V5Z 4H4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Edwin S.H Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.<br /><searchLink fieldCode="AU" term="%22Pouladi+MA%22">Pouladi MA</searchLink>; Department of Medical Genetics, Vancouver, BC V5Z 4H4, Canada.; Centre for Molecular Medicine and Therapeutics, Vancouver, BC V5Z 4H4, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Edwin S.H Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.<br /><searchLink fieldCode="AU" term="%22Edwards+AM%22">Edwards AM</searchLink>; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Wilson+DJ%22">Wilson DJ</searchLink>; Department of Chemistry, York University, Toronto, ON M3J 1P3, Canada.<br /><searchLink fieldCode="AU" term="%22Lea+SM%22">Lea SM</searchLink>; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.<br /><searchLink fieldCode="AU" term="%22Suga+H%22">Suga H</searchLink>; Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.<br /><searchLink fieldCode="AU" term="%22Harding+RJ%22">Harding RJ</searchLink>; Structural Genomics Consortium, University Health Network, Toronto, ON M5G 1L7, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada.
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