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Impact of ionizable lipid source on quality and stability of siRNA-loaded lipid nanoparticles.

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Title: Impact of ionizable lipid source on quality and stability of siRNA-loaded lipid nanoparticles.
Authors: Ranjbar S; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA., Shih KC; Malvern Panalytical, 2400 Computer Dr, Westborough, MA 01581, USA., O'Reilly Beringhs A; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Springs, MD 20993, USA., Qin B; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Springs, MD 20993, USA., Wang Y; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Springs, MD 20993, USA., Zhang D; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Springs, MD 20993, USA., Smith W; Office of Pharmaceutical Quality Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA., Seyednejad A; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA., Burroughs L; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA., Burgess D; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA., Bahal R; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA., Lu X; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA. Electronic address: xiuling.lu@uconn.edu.
Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2026 May 10; Vol. 393, pp. 114825. Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Impact of ionizable lipid source on quality and stability of siRNA-loaded lipid nanoparticles.
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  Data: <searchLink fieldCode="AU" term="%22Ranjbar+S%22">Ranjbar S</searchLink>; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.<br /><searchLink fieldCode="AU" term="%22Shih+KC%22">Shih KC</searchLink>; Malvern Panalytical, 2400 Computer Dr, Westborough, MA 01581, USA.<br /><searchLink fieldCode="AU" term="%22O'Reilly+Beringhs+A%22">O'Reilly Beringhs A</searchLink>; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Springs, MD 20993, USA.<br /><searchLink fieldCode="AU" term="%22Qin+B%22">Qin B</searchLink>; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Springs, MD 20993, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Springs, MD 20993, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+D%22">Zhang D</searchLink>; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Springs, MD 20993, USA.<br /><searchLink fieldCode="AU" term="%22Smith+W%22">Smith W</searchLink>; Office of Pharmaceutical Quality Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.<br /><searchLink fieldCode="AU" term="%22Seyednejad+A%22">Seyednejad A</searchLink>; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.<br /><searchLink fieldCode="AU" term="%22Burroughs+L%22">Burroughs L</searchLink>; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.<br /><searchLink fieldCode="AU" term="%22Burgess+D%22">Burgess D</searchLink>; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.<br /><searchLink fieldCode="AU" term="%22Bahal+R%22">Bahal R</searchLink>; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.<br /><searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA. Electronic address: xiuling.lu@uconn.edu.
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  Data: <searchLink fieldCode="JN" term="%228607908%22">Journal of controlled release : official journal of the Controlled Release Society</searchLink> [J Control Release] 2026 May 10; Vol. 393, pp. 114825. <i>Date of Electronic Publication: </i>2026 Mar 14.
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        Value: 10.1016/j.jconrel.2026.114825
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              Text: 2026 May 10
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