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Hepatic HuR modulates glucose metabolism through the C/EBPβ/PCK1 pathway.

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Title: Hepatic HuR modulates glucose metabolism through the C/EBPβ/PCK1 pathway.
Authors: Lachiondo-Ortega S; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain., González-Recio I; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain., Bravo M; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain., Gonzalez-Rellan MJ; Department of Physiology, CiMUS, Universidad de Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Sanz-Parra A; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain., Porteiro B; Department of Physiology, CiMUS, Universidad de Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Goikoetxea-Usandizaga N; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), ISCIII, Madrid, Spain., Rejano-Gordillo CM; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain., Zapata-Pavas LE; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain., Peña-Sanfélix P; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain., Conter C; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain., Barrenechea-Barrenechea JA; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain., Mercado-Gómez M; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain., Abruzzese GA; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain., Ortega FJ; Cellular and Translational Biology Group, Institut d'Investigació Biomèdica de Girona (IDIBGI), Girona, Spain; Centro de Investigación Biomédica en Red de la Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Aransay AM; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), ISCIII, Madrid, Spain; Genome Analysis Platform, CIC bioGUNE, BRTA, Derio, Bizkaia, 48160, Spain., Delgado TC; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain., Frühbeck G; Centro de Investigación Biomédica en Red de la Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain., Gorospe M; Laboratory of Genetics and Genomics, National Institute on Aging (NIA), Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA., Nogueiras R; Department of Physiology, CiMUS, Universidad de Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red de la Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Electronic address: ruben.nogueiras@usc.es., Martínez-Chantar ML; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), ISCIII, Madrid, Spain. Electronic address: mlmartinez@cicbiogune.es.
Source: Molecular metabolism [Mol Metab] 2026 May; Vol. 107, pp. 102354. Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hepatic HuR modulates glucose metabolism through the C/EBPβ/PCK1 pathway.
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  Data: <searchLink fieldCode="AU" term="%22Lachiondo-Ortega+S%22">Lachiondo-Ortega S</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain.<br /><searchLink fieldCode="AU" term="%22González-Recio+I%22">González-Recio I</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Bravo+M%22">Bravo M</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Rellan+MJ%22">Gonzalez-Rellan MJ</searchLink>; Department of Physiology, CiMUS, Universidad de Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz-Parra+A%22">Sanz-Parra A</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Porteiro+B%22">Porteiro B</searchLink>; Department of Physiology, CiMUS, Universidad de Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Goikoetxea-Usandizaga+N%22">Goikoetxea-Usandizaga N</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), ISCIII, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rejano-Gordillo+CM%22">Rejano-Gordillo CM</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Zapata-Pavas+LE%22">Zapata-Pavas LE</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Peña-Sanfélix+P%22">Peña-Sanfélix P</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Conter+C%22">Conter C</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Barrenechea-Barrenechea+JA%22">Barrenechea-Barrenechea JA</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Mercado-Gómez+M%22">Mercado-Gómez M</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Abruzzese+GA%22">Abruzzese GA</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Ortega+FJ%22">Ortega FJ</searchLink>; Cellular and Translational Biology Group, Institut d'Investigació Biomèdica de Girona (IDIBGI), Girona, Spain; Centro de Investigación Biomédica en Red de la Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Aransay+AM%22">Aransay AM</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), ISCIII, Madrid, Spain; Genome Analysis Platform, CIC bioGUNE, BRTA, Derio, Bizkaia, 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Delgado+TC%22">Delgado TC</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain.<br /><searchLink fieldCode="AU" term="%22Frühbeck+G%22">Frühbeck G</searchLink>; Centro de Investigación Biomédica en Red de la Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain.<br /><searchLink fieldCode="AU" term="%22Gorospe+M%22">Gorospe M</searchLink>; Laboratory of Genetics and Genomics, National Institute on Aging (NIA), Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Nogueiras+R%22">Nogueiras R</searchLink>; Department of Physiology, CiMUS, Universidad de Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red de la Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Electronic address: ruben.nogueiras@usc.es.<br /><searchLink fieldCode="AU" term="%22Martínez-Chantar+ML%22">Martínez-Chantar ML</searchLink>; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, 48160, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), ISCIII, Madrid, Spain. Electronic address: mlmartinez@cicbiogune.es.
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