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Freezing and thawing of biologics in bottles and downscale modelling evaluation.

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Title: Freezing and thawing of biologics in bottles and downscale modelling evaluation.
Authors: Nakach M; Sanofi R&D, 1, Impasse des ateliers 94403 Vitry sur Seine, France. Electronic address: mostafa.nakach@gmail.com., Correia C; Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal., Authelin JR; Sanofi R&D, 1, Impasse des ateliers 94403 Vitry sur Seine, France., Pauli-Bruns A; Sanofi R&D, Industriepark Höchst 65926 Frankfurt, Germany., Geraldes V; Centro de Química Estrutural, CQE, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal; SmartFreez Lda, Av. Professor Doutor Cavaco Silva, Edifício Tecnologia 1.2, no 26, 2740-257 Porto Salvo, Portugal., Rodrigues MA; Centro de Química Estrutural, CQE, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal; SmartFreez Lda, Av. Professor Doutor Cavaco Silva, Edifício Tecnologia 1.2, no 26, 2740-257 Porto Salvo, Portugal.
Source: Journal of pharmaceutical sciences [J Pharm Sci] 2026 May; Vol. 115 (5), pp. 104252. Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Nakach+M%22">Nakach M</searchLink>; Sanofi R&D, 1, Impasse des ateliers 94403 Vitry sur Seine, France. Electronic address: mostafa.nakach@gmail.com.<br /><searchLink fieldCode="AU" term="%22Correia+C%22">Correia C</searchLink>; Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Authelin+JR%22">Authelin JR</searchLink>; Sanofi R&D, 1, Impasse des ateliers 94403 Vitry sur Seine, France.<br /><searchLink fieldCode="AU" term="%22Pauli-Bruns+A%22">Pauli-Bruns A</searchLink>; Sanofi R&D, Industriepark Höchst 65926 Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Geraldes+V%22">Geraldes V</searchLink>; Centro de Química Estrutural, CQE, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal; SmartFreez Lda, Av. Professor Doutor Cavaco Silva, Edifício Tecnologia 1.2, no 26, 2740-257 Porto Salvo, Portugal.<br /><searchLink fieldCode="AU" term="%22Rodrigues+MA%22">Rodrigues MA</searchLink>; Centro de Química Estrutural, CQE, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal; SmartFreez Lda, Av. Professor Doutor Cavaco Silva, Edifício Tecnologia 1.2, no 26, 2740-257 Porto Salvo, Portugal.
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  Data: <searchLink fieldCode="JN" term="%222985195R%22">Journal of pharmaceutical sciences</searchLink> [J Pharm Sci] 2026 May; Vol. 115 (5), pp. 104252. <i>Date of Electronic Publication: </i>2026 Mar 14.
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              Text: 2026 May
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