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A selective enrichment and specific probe terminal mediated strategy for highly sensitive detection of microRNAs.

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Title: A selective enrichment and specific probe terminal mediated strategy for highly sensitive detection of microRNAs.
Authors: Zhong Z; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China., Huang W; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China., Ren J; The Second Department of Hematology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; The Second Department of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Institute of Precision Medicine, Fujian Medical University, Fuzhou, China.; Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, China., Yuan L; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong Province, China.; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China., Zhong Q; Xiamen Haicang Hospital, Xiamen, Fujian, China., Ge Y; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China., Wang J; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China., Xiang J; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China., Lin L; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China., Chen Y; Xiamen Haicang Hospital, Xiamen, Fujian, China., Xu J; The Second Department of Hematology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; The Second Department of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Institute of Precision Medicine, Fujian Medical University, Fuzhou, China., Zhang Z; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong Province, China.; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China., Li T; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China., Zhang J; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China., Hu J; Institute of Precision Medicine, Fujian Medical University, Fuzhou, China.; The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China., He S; Xiamen Haicang Hospital, Xiamen, Fujian, China. szhe@xmu.edu.cn., Tang L; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong Province, China. tanglq@sysucc.org.cn.; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China. tanglq@sysucc.org.cn., Ge S; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China. sxge@xmu.edu.cn.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China. sxge@xmu.edu.cn., Xia N; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China. nsxia@xmu.edu.cn.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China. nsxia@xmu.edu.cn., Yang T; The Second Department of Hematology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China. yang.hopeting@gmail.com.; The Second Department of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China. yang.hopeting@gmail.com.; Institute of Precision Medicine, Fujian Medical University, Fuzhou, China. yang.hopeting@gmail.com.; Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, China. yang.hopeting@gmail.com., Zhang S; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China. zhangshiyin@xmu.edu.cn.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China. zhangshiyin@xmu.edu.cn.
Source: Nature communications [Nat Commun] 2026 Mar 16; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A selective enrichment and specific probe terminal mediated strategy for highly sensitive detection of microRNAs.
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  Data: <searchLink fieldCode="AU" term="%22Zhong+Z%22">Zhong Z</searchLink>; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Ren+J%22">Ren J</searchLink>; The Second Department of Hematology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; The Second Department of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Institute of Precision Medicine, Fujian Medical University, Fuzhou, China.; Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Yuan+L%22">Yuan L</searchLink>; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong Province, China.; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Zhong+Q%22">Zhong Q</searchLink>; Xiamen Haicang Hospital, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Ge+Y%22">Ge Y</searchLink>; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Xiang+J%22">Xiang J</searchLink>; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Lin+L%22">Lin L</searchLink>; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Xiamen Haicang Hospital, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; The Second Department of Hematology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; The Second Department of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.; Institute of Precision Medicine, Fujian Medical University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong Province, China.; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Institute of Precision Medicine, Fujian Medical University, Fuzhou, China.; The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China.<br /><searchLink fieldCode="AU" term="%22He+S%22">He S</searchLink>; Xiamen Haicang Hospital, Xiamen, Fujian, China. szhe@xmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Tang+L%22">Tang L</searchLink>; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong Province, China. tanglq@sysucc.org.cn.; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China. tanglq@sysucc.org.cn.<br /><searchLink fieldCode="AU" term="%22Ge+S%22">Ge S</searchLink>; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China. sxge@xmu.edu.cn.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China. sxge@xmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xia+N%22">Xia N</searchLink>; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China. nsxia@xmu.edu.cn.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China. nsxia@xmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; The Second Department of Hematology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China. yang.hopeting@gmail.com.; The Second Department of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China. yang.hopeting@gmail.com.; Institute of Precision Medicine, Fujian Medical University, Fuzhou, China. yang.hopeting@gmail.com.; Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, China. yang.hopeting@gmail.com.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, Fujian, China. zhangshiyin@xmu.edu.cn.; NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology, School of Public Health, Xiamen University, Xiamen, Fujian, China. zhangshiyin@xmu.edu.cn.
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