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APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti-PD-1 efficacy in bladder cancer.

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Title: APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti-PD-1 efficacy in bladder cancer.
Authors: Zhang C; School of medicine, Nankai University, Tianjin, 300071, China.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China., Cao S; School of medicine, Nankai University, Tianjin, 300071, China.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China., Zeng G; School of medicine, Nankai University, Tianjin, 300071, China., Dong Y; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China.; Department of Urology Laboratory, Chinese PLA General Hospital, Beijing, China.; Medical School of PLA, Beijing, China., Li H; School of medicine, Nankai University, Tianjin, 300071, China.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China., Ma X; School of medicine, Nankai University, Tianjin, 300071, China.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China., Zhang X; School of medicine, Nankai University, Tianjin, 300071, China. xzhang301@163.com.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China. xzhang301@163.com., Li Z; School of medicine, Nankai University, Tianjin, 300071, China. dr_zhili@163.com.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China. dr_zhili@163.com., Huang Y; School of medicine, Nankai University, Tianjin, 300071, China. dr.huangyan301@foxmail.com.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China. dr.huangyan301@foxmail.com.; Department of Urology Laboratory, Chinese PLA General Hospital, Beijing, China. dr.huangyan301@foxmail.com.
Source: Scientific reports [Sci Rep] 2026 Mar 15; Vol. 16 (1). Date of Electronic Publication: 2026 Mar 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti-PD-1 efficacy in bladder cancer.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; School of medicine, Nankai University, Tianjin, 300071, China.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China.<br /><searchLink fieldCode="AU" term="%22Cao+S%22">Cao S</searchLink>; School of medicine, Nankai University, Tianjin, 300071, China.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China.<br /><searchLink fieldCode="AU" term="%22Zeng+G%22">Zeng G</searchLink>; School of medicine, Nankai University, Tianjin, 300071, China.<br /><searchLink fieldCode="AU" term="%22Dong+Y%22">Dong Y</searchLink>; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China.; Department of Urology Laboratory, Chinese PLA General Hospital, Beijing, China.; Medical School of PLA, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; School of medicine, Nankai University, Tianjin, 300071, China.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China.<br /><searchLink fieldCode="AU" term="%22Ma+X%22">Ma X</searchLink>; School of medicine, Nankai University, Tianjin, 300071, China.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; School of medicine, Nankai University, Tianjin, 300071, China. xzhang301@163.com.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China. xzhang301@163.com.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; School of medicine, Nankai University, Tianjin, 300071, China. dr_zhili@163.com.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China. dr_zhili@163.com.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; School of medicine, Nankai University, Tianjin, 300071, China. dr.huangyan301@foxmail.com.; Department of Urology, Chinese PLA General Hospital, Beijing, 100039, China. dr.huangyan301@foxmail.com.; Department of Urology Laboratory, Chinese PLA General Hospital, Beijing, China. dr.huangyan301@foxmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Mar 15; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 Mar 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41598-026-44653-8
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              Text: 2026 Mar 15
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