Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.

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Title: Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.
Authors: Chapman JA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Masi AC; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Beck LC; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Watson H; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Young GR; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Browne HP; Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK., Shao Y; Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK., Kiu R; Department of Microbes, Infection and Microbiomes, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.; Food, Microbiome and Health, Quadram Institute Bioscience, Norwich, UK., Nelson A; Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK., Doyle JA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Palmowski P; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Lengyel M; dsm-firmenich, Hørsholm, Denmark., Connolly JPR; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Lamb CA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Porter A; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Lawley TD; Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK., Hall LJ; Department of Microbes, Infection and Microbiomes, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.; Food, Microbiome and Health, Quadram Institute Bioscience, Norwich, UK.; Norwich Medical School, University of East Anglia, Norwich, UK., Embleton ND; Newcastle Neonatal Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Perry JD; Microbiology Department, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Berrington JE; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Newcastle Neonatal Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Stewart CJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. christopher.stewart@newcastle.ac.uk.
Source: Nature microbiology [Nat Microbiol] 2026 Apr; Vol. 11 (4), pp. 940-959. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2058-5276
DOI:10.1038/s41564-026-02297-4