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Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.

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Title: Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.
Authors: Chapman JA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Masi AC; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Beck LC; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Watson H; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Young GR; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Browne HP; Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK., Shao Y; Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK., Kiu R; Department of Microbes, Infection and Microbiomes, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.; Food, Microbiome and Health, Quadram Institute Bioscience, Norwich, UK., Nelson A; Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK., Doyle JA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Palmowski P; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Lengyel M; dsm-firmenich, Hørsholm, Denmark., Connolly JPR; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Lamb CA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Porter A; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Lawley TD; Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK., Hall LJ; Department of Microbes, Infection and Microbiomes, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.; Food, Microbiome and Health, Quadram Institute Bioscience, Norwich, UK.; Norwich Medical School, University of East Anglia, Norwich, UK., Embleton ND; Newcastle Neonatal Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Perry JD; Microbiology Department, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Berrington JE; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Newcastle Neonatal Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Stewart CJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. christopher.stewart@newcastle.ac.uk.
Source: Nature microbiology [Nat Microbiol] 2026 Apr; Vol. 11 (4), pp. 940-959. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article
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  Data: Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.
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  Data: <searchLink fieldCode="AU" term="%22Chapman+JA%22">Chapman JA</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Masi+AC%22">Masi AC</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Beck+LC%22">Beck LC</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Watson+H%22">Watson H</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Young+GR%22">Young GR</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Browne+HP%22">Browne HP</searchLink>; Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Shao+Y%22">Shao Y</searchLink>; Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Kiu+R%22">Kiu R</searchLink>; Department of Microbes, Infection and Microbiomes, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.; Food, Microbiome and Health, Quadram Institute Bioscience, Norwich, UK.<br /><searchLink fieldCode="AU" term="%22Nelson+A%22">Nelson A</searchLink>; Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Doyle+JA%22">Doyle JA</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Palmowski+P%22">Palmowski P</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Lengyel+M%22">Lengyel M</searchLink>; dsm-firmenich, Hørsholm, Denmark.<br /><searchLink fieldCode="AU" term="%22Connolly+JPR%22">Connolly JPR</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Lamb+CA%22">Lamb CA</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Porter+A%22">Porter A</searchLink>; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Lawley+TD%22">Lawley TD</searchLink>; Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Hall+LJ%22">Hall LJ</searchLink>; Department of Microbes, Infection and Microbiomes, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.; Food, Microbiome and Health, Quadram Institute Bioscience, Norwich, UK.; Norwich Medical School, University of East Anglia, Norwich, UK.<br /><searchLink fieldCode="AU" term="%22Embleton+ND%22">Embleton ND</searchLink>; Newcastle Neonatal Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Perry+JD%22">Perry JD</searchLink>; Microbiology Department, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Berrington+JE%22">Berrington JE</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Newcastle Neonatal Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Stewart+CJ%22">Stewart CJ</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. christopher.stewart@newcastle.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101674869%22">Nature microbiology</searchLink> [Nat Microbiol] 2026 Apr; Vol. 11 (4), pp. 940-959. <i>Date of Electronic Publication: </i>2026 Mar 16.
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