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Monocytes from inflammatory arthritis patients accumulate methotrexate and their transcriptome predicts methotrexate clinical response.

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Title: Monocytes from inflammatory arthritis patients accumulate methotrexate and their transcriptome predicts methotrexate clinical response.
Authors: Ríos I; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain., Schiaffino MT; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain., López-Navarro B; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain., Triguero-Martínez A; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; Rheumatology Service, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain., Lin M; Laboratory of Specialized Research and Diagnostics, Amsterdam University Medical Center, Amsterdam, The Netherlands., Torres-Torresano M; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain., Struys EA; Laboratory of Specialized Research and Diagnostics, Amsterdam University Medical Center, Amsterdam, The Netherlands., Álvarez S; Molecular Biology Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; School of Experimental Sciences, Biosciences Research Institute, Universidad Francisco de Vitoria, Madrid, Spain., Román M; Clinical Pharmacology Department, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain., Abad-Santos F; Clinical Pharmacology Department, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain.; Pharmacology Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain., Castañeda S; Rheumatology Service, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain., Garcia-Castañeda N; Rheumatology Service, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain., de Jonge R; Laboratory of Specialized Research and Diagnostics, Amsterdam University Medical Center, Amsterdam, The Netherlands., Jansen G; Department of Rheumatology and Clinical Immunology, Amsterdam Rheumatology and Immunology Center, Amsterdam University Medical Center, Amsterdam, The Netherlands., Castrejón I; Rheumatology Service, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain., González-Álvaro I; Rheumatology Service, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain., Puig-Kröger A; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. amaya.puig@iisgm.com.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Mar 17; Vol. 83 (1). Date of Electronic Publication: 2026 Mar 17.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1420-9071
DOI:10.1007/s00018-026-06162-9