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Monocytes from inflammatory arthritis patients accumulate methotrexate and their transcriptome predicts methotrexate clinical response.

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Title: Monocytes from inflammatory arthritis patients accumulate methotrexate and their transcriptome predicts methotrexate clinical response.
Authors: Ríos I; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain., Schiaffino MT; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain., López-Navarro B; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain., Triguero-Martínez A; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; Rheumatology Service, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain., Lin M; Laboratory of Specialized Research and Diagnostics, Amsterdam University Medical Center, Amsterdam, The Netherlands., Torres-Torresano M; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain., Struys EA; Laboratory of Specialized Research and Diagnostics, Amsterdam University Medical Center, Amsterdam, The Netherlands., Álvarez S; Molecular Biology Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; School of Experimental Sciences, Biosciences Research Institute, Universidad Francisco de Vitoria, Madrid, Spain., Román M; Clinical Pharmacology Department, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain., Abad-Santos F; Clinical Pharmacology Department, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain.; Pharmacology Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain., Castañeda S; Rheumatology Service, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain., Garcia-Castañeda N; Rheumatology Service, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain., de Jonge R; Laboratory of Specialized Research and Diagnostics, Amsterdam University Medical Center, Amsterdam, The Netherlands., Jansen G; Department of Rheumatology and Clinical Immunology, Amsterdam Rheumatology and Immunology Center, Amsterdam University Medical Center, Amsterdam, The Netherlands., Castrejón I; Rheumatology Service, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain., González-Álvaro I; Rheumatology Service, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain., Puig-Kröger A; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. amaya.puig@iisgm.com.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Mar 17; Vol. 83 (1). Date of Electronic Publication: 2026 Mar 17.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Monocytes from inflammatory arthritis patients accumulate methotrexate and their transcriptome predicts methotrexate clinical response.
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  Data: <searchLink fieldCode="AU" term="%22Ríos+I%22">Ríos I</searchLink>; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; Myeloid Cell Laboratory, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Schiaffino+MT%22">Schiaffino MT</searchLink>; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22López-Navarro+B%22">López-Navarro B</searchLink>; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Triguero-Martínez+A%22">Triguero-Martínez A</searchLink>; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; Rheumatology Service, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lin+M%22">Lin M</searchLink>; Laboratory of Specialized Research and Diagnostics, Amsterdam University Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Torres-Torresano+M%22">Torres-Torresano M</searchLink>; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Struys+EA%22">Struys EA</searchLink>; Laboratory of Specialized Research and Diagnostics, Amsterdam University Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Álvarez+S%22">Álvarez S</searchLink>; Molecular Biology Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; School of Experimental Sciences, Biosciences Research Institute, Universidad Francisco de Vitoria, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Román+M%22">Román M</searchLink>; Clinical Pharmacology Department, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Abad-Santos+F%22">Abad-Santos F</searchLink>; Clinical Pharmacology Department, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain.; Pharmacology Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Castañeda+S%22">Castañeda S</searchLink>; Rheumatology Service, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Garcia-Castañeda+N%22">Garcia-Castañeda N</searchLink>; Rheumatology Service, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22de+Jonge+R%22">de Jonge R</searchLink>; Laboratory of Specialized Research and Diagnostics, Amsterdam University Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jansen+G%22">Jansen G</searchLink>; Department of Rheumatology and Clinical Immunology, Amsterdam Rheumatology and Immunology Center, Amsterdam University Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Castrejón+I%22">Castrejón I</searchLink>; Rheumatology Service, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.; Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22González-Álvaro+I%22">González-Álvaro I</searchLink>; Rheumatology Service, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Puig-Kröger+A%22">Puig-Kröger A</searchLink>; Immunometabolism and Inflammation Laboratory, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. amaya.puig@iisgm.com.
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  Data: <searchLink fieldCode="JN" term="%229705402%22">Cellular and molecular life sciences : CMLS</searchLink> [Cell Mol Life Sci] 2026 Mar 17; Vol. 83 (1). <i>Date of Electronic Publication: </i>2026 Mar 17.
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  Data: Journal Article; Clinical Trial, Phase I
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9705402 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-9071 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221420682X%22">1420682X </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Life Sci <i>Subsets: </i>MEDLINE
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