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Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma.

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Title: Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma.
Authors: Feinberg D; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA., Uppin V; Department of Medicine, Division of Hematology/Oncology, Case Western Reserve University, Cleveland, OH, USA., Eid S; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Fritz C; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA., Hitomi M; Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH, USA.; Department of Molecular Medicine, The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA., Radhakrishnan A; Department of Medicine, Division of Hematology/Oncology, Case Western Reserve University, Cleveland, OH, USA., Klatt K; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA., Choi SH; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Myers JT; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Bhatt A; Department of Medicine, Division of Hematology/Oncology, Case Western Reserve University, Cleveland, OH, USA., Stearns D; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Division of Pediatrics-Hematology and Oncology, UH Rainbow Babies and Children's Hospital, Cleveland, OH, USA., Pateva I; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Division of Pediatrics-Hematology and Oncology, UH Rainbow Babies and Children's Hospital, Cleveland, OH, USA., Burke ZDC; Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH, USA.; Department of Orthopedic Surgery, Cleveland Clinic, Cleveland, OH, USA., Huang AY; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Division of Pediatrics-Hematology and Oncology, UH Rainbow Babies and Children's Hospital, Cleveland, OH, USA.; Center for Pediatric Immunotherapy, Angie Fowler AYA Cancer Institute, UH Rainbow Babies & Children's Hospital, Cleveland, OH, USA., Schwartz GK; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Parameswaran R; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. rxp278@case.edu.; Department of Medicine, Division of Hematology/Oncology, Case Western Reserve University, Cleveland, OH, USA. rxp278@case.edu.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. rxp278@case.edu.; Division of Pediatrics-Hematology and Oncology, UH Rainbow Babies and Children's Hospital, Cleveland, OH, USA. rxp278@case.edu.
Source: BMC medicine [BMC Med] 2026 Mar 17; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 17.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma.
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  Data: <searchLink fieldCode="AU" term="%22Feinberg+D%22">Feinberg D</searchLink>; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Uppin+V%22">Uppin V</searchLink>; Department of Medicine, Division of Hematology/Oncology, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Eid+S%22">Eid S</searchLink>; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Fritz+C%22">Fritz C</searchLink>; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hitomi+M%22">Hitomi M</searchLink>; Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH, USA.; Department of Molecular Medicine, The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Radhakrishnan+A%22">Radhakrishnan A</searchLink>; Department of Medicine, Division of Hematology/Oncology, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Klatt+K%22">Klatt K</searchLink>; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Choi+SH%22">Choi SH</searchLink>; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Myers+JT%22">Myers JT</searchLink>; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Bhatt+A%22">Bhatt A</searchLink>; Department of Medicine, Division of Hematology/Oncology, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Stearns+D%22">Stearns D</searchLink>; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Division of Pediatrics-Hematology and Oncology, UH Rainbow Babies and Children's Hospital, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Pateva+I%22">Pateva I</searchLink>; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Division of Pediatrics-Hematology and Oncology, UH Rainbow Babies and Children's Hospital, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Burke+ZDC%22">Burke ZDC</searchLink>; Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH, USA.; Department of Orthopedic Surgery, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Huang+AY%22">Huang AY</searchLink>; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Division of Pediatrics-Hematology and Oncology, UH Rainbow Babies and Children's Hospital, Cleveland, OH, USA.; Center for Pediatric Immunotherapy, Angie Fowler AYA Cancer Institute, UH Rainbow Babies & Children's Hospital, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Schwartz+GK%22">Schwartz GK</searchLink>; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Parameswaran+R%22">Parameswaran R</searchLink>; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. rxp278@case.edu.; Department of Medicine, Division of Hematology/Oncology, Case Western Reserve University, Cleveland, OH, USA. rxp278@case.edu.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. rxp278@case.edu.; Division of Pediatrics-Hematology and Oncology, UH Rainbow Babies and Children's Hospital, Cleveland, OH, USA. rxp278@case.edu.
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  Data: <searchLink fieldCode="JN" term="%22101190723%22">BMC medicine</searchLink> [BMC Med] 2026 Mar 17; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Mar 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190723 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1741-7015 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217417015%22">17417015 </searchLink><i>NLM ISO Abbreviation: </i>BMC Med <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12916-026-04729-8
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