Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients: The R2D2-ICU Randomized Clinical Trial.
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| Title: | Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients: The R2D2-ICU Randomized Clinical Trial. |
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| Authors: | Sonneville R; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France., Couffignal C; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France., Sigaud F; Medical Intensive Care Unit, Grenoble Alpes University Hospital, La Tronche, France., Thy M; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France., Godard V; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France., Audibert J; Department of Intensive Care, Chartres Hospital, Chartres, France., Contou D; Department of Intensive Care Medicine, Victor Dupouy Hospital, Argenteuil, France., Celier A; APHP-Sorbonne Université, Pitié-Salpêtrière University Hospital, Department of Intensive Care Medicine R3S, Paris, France., Djibré M; Medical Intensive Care Unit, Tenon Hospital, Assistance Publique-Hôpitaux de Paris, France., Rambaud T; Medical Intensive Care Unit, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France., Jaquet P; Medical Intensive Care Unit, Delafontaine Hospital, Saint-Denis, France., Mekontso Dessap A; Medical Intensive Care Unit, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France., Bourel C; Medical Intensive Care Unit, Lille University Hospital, Lille, France., Belot R; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France., Roy C; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France., Nait Sidenas F; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France., Essardy F; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France., Timsit JF; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France., Cornic R; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France., Bouadma L; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France. |
| Corporate Authors: | R2D2-ICU Investigator Study Group |
| Source: | JAMA [JAMA] 2026 Apr 14; Vol. 335 (14), pp. 1232-1242. |
| Publication Type: | Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1538-3598 |
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| DOI: | 10.1001/jama.2026.2897 |
