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Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients: The R2D2-ICU Randomized Clinical Trial.

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Title: Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients: The R2D2-ICU Randomized Clinical Trial.
Authors: Sonneville R; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France., Couffignal C; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France., Sigaud F; Medical Intensive Care Unit, Grenoble Alpes University Hospital, La Tronche, France., Thy M; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France., Godard V; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France., Audibert J; Department of Intensive Care, Chartres Hospital, Chartres, France., Contou D; Department of Intensive Care Medicine, Victor Dupouy Hospital, Argenteuil, France., Celier A; APHP-Sorbonne Université, Pitié-Salpêtrière University Hospital, Department of Intensive Care Medicine R3S, Paris, France., Djibré M; Medical Intensive Care Unit, Tenon Hospital, Assistance Publique-Hôpitaux de Paris, France., Rambaud T; Medical Intensive Care Unit, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France., Jaquet P; Medical Intensive Care Unit, Delafontaine Hospital, Saint-Denis, France., Mekontso Dessap A; Medical Intensive Care Unit, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France., Bourel C; Medical Intensive Care Unit, Lille University Hospital, Lille, France., Belot R; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France., Roy C; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France., Nait Sidenas F; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France., Essardy F; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France., Timsit JF; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France., Cornic R; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France., Bouadma L; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France.
Corporate Authors: R2D2-ICU Investigator Study Group
Source: JAMA [JAMA] 2026 Apr 14; Vol. 335 (14), pp. 1232-1242.
Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients: The R2D2-ICU Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Sonneville+R%22">Sonneville R</searchLink>; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France.<br /><searchLink fieldCode="AU" term="%22Couffignal+C%22">Couffignal C</searchLink>; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France.<br /><searchLink fieldCode="AU" term="%22Sigaud+F%22">Sigaud F</searchLink>; Medical Intensive Care Unit, Grenoble Alpes University Hospital, La Tronche, France.<br /><searchLink fieldCode="AU" term="%22Thy+M%22">Thy M</searchLink>; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France.<br /><searchLink fieldCode="AU" term="%22Godard+V%22">Godard V</searchLink>; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France.<br /><searchLink fieldCode="AU" term="%22Audibert+J%22">Audibert J</searchLink>; Department of Intensive Care, Chartres Hospital, Chartres, France.<br /><searchLink fieldCode="AU" term="%22Contou+D%22">Contou D</searchLink>; Department of Intensive Care Medicine, Victor Dupouy Hospital, Argenteuil, France.<br /><searchLink fieldCode="AU" term="%22Celier+A%22">Celier A</searchLink>; APHP-Sorbonne Université, Pitié-Salpêtrière University Hospital, Department of Intensive Care Medicine R3S, Paris, France.<br /><searchLink fieldCode="AU" term="%22Djibré+M%22">Djibré M</searchLink>; Medical Intensive Care Unit, Tenon Hospital, Assistance Publique-Hôpitaux de Paris, France.<br /><searchLink fieldCode="AU" term="%22Rambaud+T%22">Rambaud T</searchLink>; Medical Intensive Care Unit, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France.<br /><searchLink fieldCode="AU" term="%22Jaquet+P%22">Jaquet P</searchLink>; Medical Intensive Care Unit, Delafontaine Hospital, Saint-Denis, France.<br /><searchLink fieldCode="AU" term="%22Mekontso+Dessap+A%22">Mekontso Dessap A</searchLink>; Medical Intensive Care Unit, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Bourel+C%22">Bourel C</searchLink>; Medical Intensive Care Unit, Lille University Hospital, Lille, France.<br /><searchLink fieldCode="AU" term="%22Belot+R%22">Belot R</searchLink>; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France.<br /><searchLink fieldCode="AU" term="%22Roy+C%22">Roy C</searchLink>; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France.<br /><searchLink fieldCode="AU" term="%22Nait+Sidenas+F%22">Nait Sidenas F</searchLink>; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France.<br /><searchLink fieldCode="AU" term="%22Essardy+F%22">Essardy F</searchLink>; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France.<br /><searchLink fieldCode="AU" term="%22Timsit+JF%22">Timsit JF</searchLink>; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cornic+R%22">Cornic R</searchLink>; AP-HP.Nord, Epidemiology, Biostatistics, and Clinical Research, Bichat-Claude Bernard University Hospital, DMU PRISME, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bouadma+L%22">Bouadma L</searchLink>; Université Paris Cité, IAME, INSERM UMR 1137, Paris, France.; AP-HP.Nord, Department of Intensive Care Medicine, Bichat-Claude Bernard University Hospital, DMU INVICTUS, Paris, France.
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