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Phosphoproteomics elucidates the functional impact of the PTPN11 p.Asn308Ser variant in a Noonan syndrome pedigree.

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Title: Phosphoproteomics elucidates the functional impact of the PTPN11 p.Asn308Ser variant in a Noonan syndrome pedigree.
Authors: Xu WJ; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Xie LJ; The department of oncology, Zhangzhou Traditional Chinese Medicine Hospital, Zhangzhou, China., Chen WJ; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Chen JB; Institute of Molecular Engineering Plus, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108, China., Zou J; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Xu ZY; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Wang RL; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Wang XL; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Wei J; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Zhang JH; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Chen Q; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Yu HP; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Ruan DD; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China; Department of Nephrology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China., Gao MZ; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China; Department of Nephrology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China., Zhang L; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China; Department of Nephrology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China., Zhu YB; Department of Traditional Chinese Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China., Huang FM; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China. Electronic address: 2239037073@qq.com., Liao LS; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China; Department of Hematology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. Electronic address: liaolisheng@126.com., Luo JW; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China. Electronic address: docluo0421@aliyun.com., Lin XF; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China. Electronic address: 418665840@qq.com.
Source: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2026 May 15; Vol. 1276, pp. 124972. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phosphoproteomics elucidates the functional impact of the PTPN11 p.Asn308Ser variant in a Noonan syndrome pedigree.
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  Data: <searchLink fieldCode="AU" term="%22Xu+WJ%22">Xu WJ</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Xie+LJ%22">Xie LJ</searchLink>; The department of oncology, Zhangzhou Traditional Chinese Medicine Hospital, Zhangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+WJ%22">Chen WJ</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+JB%22">Chen JB</searchLink>; Institute of Molecular Engineering Plus, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108, China.<br /><searchLink fieldCode="AU" term="%22Zou+J%22">Zou J</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+ZY%22">Xu ZY</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+RL%22">Wang RL</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+XL%22">Wang XL</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Wei+J%22">Wei J</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+JH%22">Zhang JH</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Yu+HP%22">Yu HP</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Ruan+DD%22">Ruan DD</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China; Department of Nephrology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Gao+MZ%22">Gao MZ</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China; Department of Nephrology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China; Department of Nephrology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhu+YB%22">Zhu YB</searchLink>; Department of Traditional Chinese Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+FM%22">Huang FM</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China. Electronic address: 2239037073@qq.com.<br /><searchLink fieldCode="AU" term="%22Liao+LS%22">Liao LS</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China; Department of Hematology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. Electronic address: liaolisheng@126.com.<br /><searchLink fieldCode="AU" term="%22Luo+JW%22">Luo JW</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China. Electronic address: docluo0421@aliyun.com.<br /><searchLink fieldCode="AU" term="%22Lin+XF%22">Lin XF</searchLink>; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China. Electronic address: 418665840@qq.com.
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  Data: <searchLink fieldCode="JN" term="%22101139554%22">Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</searchLink> [J Chromatogr B Analyt Technol Biomed Life Sci] 2026 May 15; Vol. 1276, pp. 124972. <i>Date of Electronic Publication: </i>2026 Feb 17.
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