Phosphoproteomics elucidates the functional impact of the PTPN11 p.Asn308Ser variant in a Noonan syndrome pedigree.
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| Title: | Phosphoproteomics elucidates the functional impact of the PTPN11 p.Asn308Ser variant in a Noonan syndrome pedigree. |
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| Authors: | Xu WJ; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Xie LJ; The department of oncology, Zhangzhou Traditional Chinese Medicine Hospital, Zhangzhou, China., Chen WJ; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Chen JB; Institute of Molecular Engineering Plus, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108, China., Zou J; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Xu ZY; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Wang RL; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Wang XL; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Wei J; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Zhang JH; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Chen Q; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Yu HP; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China., Ruan DD; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China; Department of Nephrology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China., Gao MZ; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China; Department of Nephrology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China., Zhang L; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China; Department of Nephrology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China., Zhu YB; Department of Traditional Chinese Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China., Huang FM; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China. Electronic address: 2239037073@qq.com., Liao LS; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China; Department of Hematology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. Electronic address: liaolisheng@126.com., Luo JW; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China. Electronic address: docluo0421@aliyun.com., Lin XF; Department of Traditional Chinese Medicine and paediatrics, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, China. Electronic address: 418665840@qq.com. |
| Source: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2026 May 15; Vol. 1276, pp. 124972. Date of Electronic Publication: 2026 Feb 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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