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Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks.

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Title: Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks.
Authors: Li S; College of Life Sciences, Tianjin Normal University, Tianjin 300387, China; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Zhao Y; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; College of Life Sciences, Capital Normal University, Beijing 100037, China., Li Y; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; College of Life Sciences, Capital Normal University, Beijing 100037, China., Shah SB; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Shi Y; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Nguyen T; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Wang Z; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Chang CY; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Ray A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Bu TH; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Loguercio S; Scripps Research Translational Institute, La Jolla, CA 92037, USA., Sasaki T; San Diego Biomedical Research Institute, San Diego, CA 92121, USA., Sussman JH; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Wang H; College of Life Sciences, Capital Normal University, Beijing 100037, China., Gilbert DM; San Diego Biomedical Research Institute, San Diego, CA 92121, USA., Aladjem MI; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Wu X; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: xiaohwu@scripps.edu.
Source: Molecular cell [Mol Cell] 2026 Apr 02; Vol. 86 (7), pp. 1230-1246.e8. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
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  Data: Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks.
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  Data: <searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; College of Life Sciences, Tianjin Normal University, Tianjin 300387, China; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; College of Life Sciences, Capital Normal University, Beijing 100037, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; College of Life Sciences, Capital Normal University, Beijing 100037, China.<br /><searchLink fieldCode="AU" term="%22Shah+SB%22">Shah SB</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+T%22">Nguyen T</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Chang+CY%22">Chang CY</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Ray+A%22">Ray A</searchLink>; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Bu+TH%22">Bu TH</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Loguercio+S%22">Loguercio S</searchLink>; Scripps Research Translational Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Sasaki+T%22">Sasaki T</searchLink>; San Diego Biomedical Research Institute, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Sussman+JH%22">Sussman JH</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; College of Life Sciences, Capital Normal University, Beijing 100037, China.<br /><searchLink fieldCode="AU" term="%22Gilbert+DM%22">Gilbert DM</searchLink>; San Diego Biomedical Research Institute, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Aladjem+MI%22">Aladjem MI</searchLink>; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: xiaohwu@scripps.edu.
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  Data: <searchLink fieldCode="JN" term="%229802571%22">Molecular cell</searchLink> [Mol Cell] 2026 Apr 02; Vol. 86 (7), pp. 1230-1246.e8. <i>Date of Electronic Publication: </i>2026 Mar 16.
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              Text: 2026 Apr 02
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