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Multimodal imaging reveals a lysosomal drug reservoir that drives heterogeneous distribution of PARP inhibitors.

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Title: Multimodal imaging reveals a lysosomal drug reservoir that drives heterogeneous distribution of PARP inhibitors.
Authors: R Moncayo C; MRC Laboratory of Medical Sciences, London, UK., Restuadi R; Institute of Clinical Sciences, Imperial College London, London, UK., Zhang G; MRC Laboratory of Medical Sciences, London, UK., Marks D; Department of Surgery and Cancer, Imperial College London, London, UK., Ortega-Prieto P; MRC Laboratory of Medical Sciences, London, UK., Doherty E; Institute of Clinical Sciences, Imperial College London, London, UK., Lambie N; Imperial BRC Genomics Facility, Imperial College London, London, UK., Whilding C; MRC Laboratory of Medical Sciences, London, UK., Andrew I; MRC Laboratory of Medical Sciences, London, UK., Montoya A; MRC Laboratory of Medical Sciences, London, UK., Patel B; MRC Laboratory of Medical Sciences, London, UK., Tyson K; Department of Surgery and Cancer, Imperial College London, London, UK., Pennycook BR; Institute of Clinical Sciences, Imperial College London, London, UK., Pendergast L; Division of Oncology, Washington University School of Medicine, St. Louis, MO, USA., Wu V; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Takats Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Matthews N; Imperial BRC Genomics Facility, Imperial College London, London, UK., Young GR; MRC Laboratory of Medical Sciences, London, UK., Verma P; Division of Oncology, Washington University School of Medicine, St. Louis, MO, USA., Shliaha P; MRC Laboratory of Medical Sciences, London, UK., Game L; MRC Laboratory of Medical Sciences, London, UK., Lenhard B; MRC Laboratory of Medical Sciences, London, UK.; Institute of Clinical Sciences, Imperial College London, London, UK., McNeish I; Department of Surgery and Cancer, Imperial College London, London, UK., Fotopoulou C; Department of Surgery and Cancer, Imperial College London, London, UK., Barr AR; MRC Laboratory of Medical Sciences, London, UK.; Institute of Clinical Sciences, Imperial College London, London, UK., Cunnea P; Department of Surgery and Cancer, Imperial College London, London, UK., Hall Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. zoe.hall@imperial.ac.uk., Fets L; MRC Laboratory of Medical Sciences, London, UK. l.fets@lms.mrc.ac.uk.; Institute of Clinical Sciences, Imperial College London, London, UK. l.fets@lms.mrc.ac.uk.
Source: Nature communications [Nat Commun] 2026 Mar 17; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Multimodal imaging reveals a lysosomal drug reservoir that drives heterogeneous distribution of PARP inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22R+Moncayo+C%22">R Moncayo C</searchLink>; MRC Laboratory of Medical Sciences, London, UK.<br /><searchLink fieldCode="AU" term="%22Restuadi+R%22">Restuadi R</searchLink>; Institute of Clinical Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Zhang+G%22">Zhang G</searchLink>; MRC Laboratory of Medical Sciences, London, UK.<br /><searchLink fieldCode="AU" term="%22Marks+D%22">Marks D</searchLink>; Department of Surgery and Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ortega-Prieto+P%22">Ortega-Prieto P</searchLink>; MRC Laboratory of Medical Sciences, London, UK.<br /><searchLink fieldCode="AU" term="%22Doherty+E%22">Doherty E</searchLink>; Institute of Clinical Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lambie+N%22">Lambie N</searchLink>; Imperial BRC Genomics Facility, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Whilding+C%22">Whilding C</searchLink>; MRC Laboratory of Medical Sciences, London, UK.<br /><searchLink fieldCode="AU" term="%22Andrew+I%22">Andrew I</searchLink>; MRC Laboratory of Medical Sciences, London, UK.<br /><searchLink fieldCode="AU" term="%22Montoya+A%22">Montoya A</searchLink>; MRC Laboratory of Medical Sciences, London, UK.<br /><searchLink fieldCode="AU" term="%22Patel+B%22">Patel B</searchLink>; MRC Laboratory of Medical Sciences, London, UK.<br /><searchLink fieldCode="AU" term="%22Tyson+K%22">Tyson K</searchLink>; Department of Surgery and Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Pennycook+BR%22">Pennycook BR</searchLink>; Institute of Clinical Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Pendergast+L%22">Pendergast L</searchLink>; Division of Oncology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Wu+V%22">Wu V</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Takats+Z%22">Takats Z</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Matthews+N%22">Matthews N</searchLink>; Imperial BRC Genomics Facility, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Young+GR%22">Young GR</searchLink>; MRC Laboratory of Medical Sciences, London, UK.<br /><searchLink fieldCode="AU" term="%22Verma+P%22">Verma P</searchLink>; Division of Oncology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Shliaha+P%22">Shliaha P</searchLink>; MRC Laboratory of Medical Sciences, London, UK.<br /><searchLink fieldCode="AU" term="%22Game+L%22">Game L</searchLink>; MRC Laboratory of Medical Sciences, London, UK.<br /><searchLink fieldCode="AU" term="%22Lenhard+B%22">Lenhard B</searchLink>; MRC Laboratory of Medical Sciences, London, UK.; Institute of Clinical Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22McNeish+I%22">McNeish I</searchLink>; Department of Surgery and Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Fotopoulou+C%22">Fotopoulou C</searchLink>; Department of Surgery and Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Barr+AR%22">Barr AR</searchLink>; MRC Laboratory of Medical Sciences, London, UK.; Institute of Clinical Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Cunnea+P%22">Cunnea P</searchLink>; Department of Surgery and Cancer, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Hall+Z%22">Hall Z</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. zoe.hall@imperial.ac.uk.<br /><searchLink fieldCode="AU" term="%22Fets+L%22">Fets L</searchLink>; MRC Laboratory of Medical Sciences, London, UK. l.fets@lms.mrc.ac.uk.; Institute of Clinical Sciences, Imperial College London, London, UK. l.fets@lms.mrc.ac.uk.
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