Multimodal imaging reveals a lysosomal drug reservoir that drives heterogeneous distribution of PARP inhibitors.
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| Title: | Multimodal imaging reveals a lysosomal drug reservoir that drives heterogeneous distribution of PARP inhibitors. |
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| Authors: | R Moncayo C; MRC Laboratory of Medical Sciences, London, UK., Restuadi R; Institute of Clinical Sciences, Imperial College London, London, UK., Zhang G; MRC Laboratory of Medical Sciences, London, UK., Marks D; Department of Surgery and Cancer, Imperial College London, London, UK., Ortega-Prieto P; MRC Laboratory of Medical Sciences, London, UK., Doherty E; Institute of Clinical Sciences, Imperial College London, London, UK., Lambie N; Imperial BRC Genomics Facility, Imperial College London, London, UK., Whilding C; MRC Laboratory of Medical Sciences, London, UK., Andrew I; MRC Laboratory of Medical Sciences, London, UK., Montoya A; MRC Laboratory of Medical Sciences, London, UK., Patel B; MRC Laboratory of Medical Sciences, London, UK., Tyson K; Department of Surgery and Cancer, Imperial College London, London, UK., Pennycook BR; Institute of Clinical Sciences, Imperial College London, London, UK., Pendergast L; Division of Oncology, Washington University School of Medicine, St. Louis, MO, USA., Wu V; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Takats Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Matthews N; Imperial BRC Genomics Facility, Imperial College London, London, UK., Young GR; MRC Laboratory of Medical Sciences, London, UK., Verma P; Division of Oncology, Washington University School of Medicine, St. Louis, MO, USA., Shliaha P; MRC Laboratory of Medical Sciences, London, UK., Game L; MRC Laboratory of Medical Sciences, London, UK., Lenhard B; MRC Laboratory of Medical Sciences, London, UK.; Institute of Clinical Sciences, Imperial College London, London, UK., McNeish I; Department of Surgery and Cancer, Imperial College London, London, UK., Fotopoulou C; Department of Surgery and Cancer, Imperial College London, London, UK., Barr AR; MRC Laboratory of Medical Sciences, London, UK.; Institute of Clinical Sciences, Imperial College London, London, UK., Cunnea P; Department of Surgery and Cancer, Imperial College London, London, UK., Hall Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. zoe.hall@imperial.ac.uk., Fets L; MRC Laboratory of Medical Sciences, London, UK. l.fets@lms.mrc.ac.uk.; Institute of Clinical Sciences, Imperial College London, London, UK. l.fets@lms.mrc.ac.uk. |
| Source: | Nature communications [Nat Commun] 2026 Mar 17; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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