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Dichotomous SMAD2/3 regulation and selective antihypertrophic activity of heparin during in vitro chondrogenesis of mesenchymal stromal cells.

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Title: Dichotomous SMAD2/3 regulation and selective antihypertrophic activity of heparin during in vitro chondrogenesis of mesenchymal stromal cells.
Authors: Schmidt S; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany., Chasan S; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany., Dietmar HF; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany., Klampfleuthner FAM; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany., Hesse E; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany., Walker T; Department for Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany., Freudenberg U; Leibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Centre of Biomaterials Dresden (MBC), Centre for Regenerative Therapies Dresden (CRTD), Dresden University of Technology, Dresden, Germany., Richter W; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany., Diederichs S; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany. solvig.diederichs@med.uni-heidelberg.de.
Source: Cellular & molecular biology letters [Cell Mol Biol Lett] 2026 Mar 17; Vol. 31 (1). Date of Electronic Publication: 2026 Mar 17.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9607427 Publication Model: Electronic Cited Medium: Internet ISSN: 1689-1392 (Electronic) Linking ISSN: 14258153 NLM ISO Abbreviation: Cell Mol Biol Lett Subsets: MEDLINE
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  Data: Dichotomous SMAD2/3 regulation and selective antihypertrophic activity of heparin during in vitro chondrogenesis of mesenchymal stromal cells.
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  Data: <searchLink fieldCode="AU" term="%22Schmidt+S%22">Schmidt S</searchLink>; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Chasan+S%22">Chasan S</searchLink>; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Dietmar+HF%22">Dietmar HF</searchLink>; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Klampfleuthner+FAM%22">Klampfleuthner FAM</searchLink>; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hesse+E%22">Hesse E</searchLink>; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Walker+T%22">Walker T</searchLink>; Department for Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Freudenberg+U%22">Freudenberg U</searchLink>; Leibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Centre of Biomaterials Dresden (MBC), Centre for Regenerative Therapies Dresden (CRTD), Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Richter+W%22">Richter W</searchLink>; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Diederichs+S%22">Diederichs S</searchLink>; Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Department for Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany. solvig.diederichs@med.uni-heidelberg.de.
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  Data: <searchLink fieldCode="JN" term="%229607427%22">Cellular & molecular biology letters</searchLink> [Cell Mol Biol Lett] 2026 Mar 17; Vol. 31 (1). <i>Date of Electronic Publication: </i>2026 Mar 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607427 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1689-1392 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214258153%22">14258153 </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Biol Lett <i>Subsets: </i>MEDLINE
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              Text: 2026 Mar 17
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