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Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence.

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Title: Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence.
Authors: Xu Y; Department of Rehabilitation Medicine, Third Xiangya Hospital, Central South University, Changsha, China., Li X; Department of Rehabilitation Medicine, Third Xiangya Hospital, Central South University, Changsha, China., Munoz A; Centro Universitario del Norte, Universidad de Guadalajara, Colotlán, Mexico., Jiang L; Department of Rehabilitation Medicine, Third Xiangya Hospital, Central South University, Changsha, China., Huang L; Center for Experimental Medicine, Third Xiangya Hospital, Central South University, Changsha, China., Zhou Y; Department of Rehabilitation Medicine, Third Xiangya Hospital, Central South University, Changsha, China., Zhu L; Department of Rehabilitation Medicine, Third Xiangya Hospital, Central South University, Changsha, China., Yang Y; Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha, China.
Source: Animal models and experimental medicine [Animal Model Exp Med] 2026 Apr; Vol. 9 (4), pp. 796-808. Date of Electronic Publication: 2026 Mar 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101726292 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-2095 (Electronic) Linking ISSN: 25762095 NLM ISO Abbreviation: Animal Model Exp Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence.
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  Data: <searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Rehabilitation Medicine, Third Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Rehabilitation Medicine, Third Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Munoz+A%22">Munoz A</searchLink>; Centro Universitario del Norte, Universidad de Guadalajara, Colotlán, Mexico.<br /><searchLink fieldCode="AU" term="%22Jiang+L%22">Jiang L</searchLink>; Department of Rehabilitation Medicine, Third Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Huang+L%22">Huang L</searchLink>; Center for Experimental Medicine, Third Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of Rehabilitation Medicine, Third Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Zhu+L%22">Zhu L</searchLink>; Department of Rehabilitation Medicine, Third Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha, China.
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  Data: <searchLink fieldCode="JN" term="%22101726292%22">Animal models and experimental medicine</searchLink> [Animal Model Exp Med] 2026 Apr; Vol. 9 (4), pp. 796-808. <i>Date of Electronic Publication: </i>2026 Mar 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Inc%22">John Wiley & Sons, Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101726292 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2576-2095 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225762095%22">25762095 </searchLink><i>NLM ISO Abbreviation: </i>Animal Model Exp Med <i>Subsets: </i>MEDLINE
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        Value: 10.1002/ame2.70171
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        Text: English
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      – TitleFull: Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence.
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            NameFull: Xu Y
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              M: 04
              Text: 2026 Apr
              Type: published
              Y: 2026
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