Patient-derived xenograft models of primary breast cancer for preclinical evaluation of neoadjuvant therapies.

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Title: Patient-derived xenograft models of primary breast cancer for preclinical evaluation of neoadjuvant therapies.
Authors: Hutten SJ; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands., Chao X; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands., Badoux M; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands., Eijkman T; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands., Sheinman M; Institute of Advanced Studies, Sevastopol State University, Sevastopol, Russia., de Bruijn R; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands.; Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands., Herencia-Ropero A; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona 08035, Spain.; Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona, Barcelona, Spain., Llop-Guevara A; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona 08035, Spain., Lutz C; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands., Wesseling J; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Division of Diagnostic Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam 1066CX, Netherlands., Serra V; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona 08035, Spain., van Rheenen J; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands., Scheele CLGJ; Center for Cancer Biology, VIB, Department of Oncology, KU Leuven, Leuven 3000, Belgium., Jonkers J; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands.
Corporate Authors: Grand Challenge PRECISION Consortium
Source: Science translational medicine [Sci Transl Med] 2026 Mar 18; Vol. 18 (841), pp. eads9088. Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Patient-derived xenograft models of primary breast cancer for preclinical evaluation of neoadjuvant therapies.
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  Data: <searchLink fieldCode="AU" term="%22Hutten+SJ%22">Hutten SJ</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Chao+X%22">Chao X</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Badoux+M%22">Badoux M</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Eijkman+T%22">Eijkman T</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Sheinman+M%22">Sheinman M</searchLink>; Institute of Advanced Studies, Sevastopol State University, Sevastopol, Russia.<br /><searchLink fieldCode="AU" term="%22de+Bruijn+R%22">de Bruijn R</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands.; Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.<br /><searchLink fieldCode="AU" term="%22Herencia-Ropero+A%22">Herencia-Ropero A</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona 08035, Spain.; Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Llop-Guevara+A%22">Llop-Guevara A</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona 08035, Spain.<br /><searchLink fieldCode="AU" term="%22Lutz+C%22">Lutz C</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Wesseling+J%22">Wesseling J</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Division of Diagnostic Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam 1066CX, Netherlands.<br /><searchLink fieldCode="AU" term="%22Serra+V%22">Serra V</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona 08035, Spain.<br /><searchLink fieldCode="AU" term="%22van+Rheenen+J%22">van Rheenen J</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Scheele+CLGJ%22">Scheele CLGJ</searchLink>; Center for Cancer Biology, VIB, Department of Oncology, KU Leuven, Leuven 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Jonkers+J%22">Jonkers J</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam 1066CX, Netherlands.; Oncode Institute, Amsterdam, Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 Mar 18; Vol. 18 (841), pp. eads9088. <i>Date of Electronic Publication: </i>2026 Mar 18.
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              Text: 2026 Mar 18
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