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Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation.

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Title: Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation.
Authors: Landmesser U; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Charité University Medicine Berlin, Berlin.; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.; Friede Springer Cardiovascular Prevention Center, Berlin., Skurk C; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Charité University Medicine Berlin, Berlin.; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin., Kirchhof P; Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.; DZHK Partner Site Hamburg-Kiel-Lübeck, Hamburg, Germany.; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom., Lewalter T; Department of Cardiology and Intensive Care Unit, Hospital Munich South, Peter Osypka Heart Center, Munich, Germany., Hartung J; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Charité University Medicine Berlin, Berlin.; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin., Rroku A; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Charité University Medicine Berlin, Berlin., Pieske B; Division of Cardiology, Department of Internal Medicine, University Medicine Rostock, Rostock, Germany., Brachmann J; Department of Cardiology, Klinikum Coburg, Coburg, Germany., Akin I; Department of Cardiology, Hemostaseology, and Medical Intensive Care, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Jacobshagen C; Department of Cardiology, Intensive Care Medicine, and Angiology, Vincentius-Diakonissen Hospital, Karlsruhe, Germany., Meder B; Precision Digital Health, Department of Internal Medicine III, Cardiology, University Heidelberg, Heidelberg, Germany.; DZHK Partner Site Heidelberg, Heidelberg, Germany., Zeiher A; Department of Medicine III, Goethe University, Frankfurt am Main, Germany.; DZHK Partner Site Rhein-Main, Frankfurt, Germany., Anker SD; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.; Institute of Health Center for Regenerative Therapies, Charité University Medicine, Berlin., Thiele H; Department of Internal Medicine-Cardiology, Heart Center at Leipzig University, Leipzig, Germany., Blankenberg S; Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.; DZHK Partner Site Hamburg-Kiel-Lübeck, Hamburg, Germany., Massberg S; Department of Medicine I, LMU University Hospital, Ludwig Maximillian University of Munich, Munich, Germany.; DZHK Partner Site Munich, Munich Heart Alliance, Munich, Germany., Schunkert H; DZHK Partner Site Munich, Munich Heart Alliance, Munich, Germany.; Department of Cardiovascular Diseases, German Heart Center, School of Medicine and Health, TUM University Hospital, Technical University of Munich, Munich, Germany., Frey N; Precision Digital Health, Department of Internal Medicine III, Cardiology, University Heidelberg, Heidelberg, Germany.; DZHK Partner Site Heidelberg, Heidelberg, Germany., Joost A; DZHK Partner Site Hamburg-Kiel-Lübeck, Hamburg, Germany.; University Heart Center Lübeck, Medical Clinic II (Cardiology-Angiology-Intensive Care Medicine), Lübeck, Germany., Bergmann M; Department of Cardiology, Asklepios Klinik Altona, Hamburg, Germany., von Bardeleben RS; Department of Cardiology, University Medical Center, Mainz, Germany., Friede T; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.; DZHK Partner Site Lower Saxony, Göttingen, Germany., Placzek M; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.; DZHK Partner Site Lower Saxony, Göttingen, Germany., Suling A; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Haeusler KG; Department of Neurology, University Hospital Ulm, Ulm, Germany., Endres M; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.; Department of Neurology, Charité University Medicine Berlin, Berlin., Wegscheider K; DZHK Partner Site Hamburg-Kiel-Lübeck, Hamburg, Germany.; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Boldt LH; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité; Campus Virchow, Berlin., Eitel I; DZHK Partner Site Hamburg-Kiel-Lübeck, Hamburg, Germany.; University Heart Center Lübeck, Medical Clinic II (Cardiology-Angiology-Intensive Care Medicine), Lübeck, Germany.
Corporate Authors: CLOSURE-AF Trial Investigators
Source: The New England journal of medicine [N Engl J Med] 2026 Apr 02; Vol. 394 (13), pp. 1270-1280. Date of Electronic Publication: 2026 Mar 18.
Publication Type: Clinical Trial, Phase IV; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Landmesser+U%22">Landmesser U</searchLink>; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Charité University Medicine Berlin, Berlin.; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.; Friede Springer Cardiovascular Prevention Center, Berlin.<br /><searchLink fieldCode="AU" term="%22Skurk+C%22">Skurk C</searchLink>; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Charité University Medicine Berlin, Berlin.; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.<br /><searchLink fieldCode="AU" term="%22Kirchhof+P%22">Kirchhof P</searchLink>; Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.; DZHK Partner Site Hamburg-Kiel-Lübeck, Hamburg, Germany.; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lewalter+T%22">Lewalter T</searchLink>; Department of Cardiology and Intensive Care Unit, Hospital Munich South, Peter Osypka Heart Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hartung+J%22">Hartung J</searchLink>; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Charité University Medicine Berlin, Berlin.; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.<br /><searchLink fieldCode="AU" term="%22Rroku+A%22">Rroku A</searchLink>; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Charité University Medicine Berlin, Berlin.<br /><searchLink fieldCode="AU" term="%22Pieske+B%22">Pieske B</searchLink>; Division of Cardiology, Department of Internal Medicine, University Medicine Rostock, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Brachmann+J%22">Brachmann J</searchLink>; Department of Cardiology, Klinikum Coburg, Coburg, Germany.<br /><searchLink fieldCode="AU" term="%22Akin+I%22">Akin I</searchLink>; Department of Cardiology, Hemostaseology, and Medical Intensive Care, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Jacobshagen+C%22">Jacobshagen C</searchLink>; Department of Cardiology, Intensive Care Medicine, and Angiology, Vincentius-Diakonissen Hospital, Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Meder+B%22">Meder B</searchLink>; Precision Digital Health, Department of Internal Medicine III, Cardiology, University Heidelberg, Heidelberg, Germany.; DZHK Partner Site Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zeiher+A%22">Zeiher A</searchLink>; Department of Medicine III, Goethe University, Frankfurt am Main, Germany.; DZHK Partner Site Rhein-Main, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Anker+SD%22">Anker SD</searchLink>; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.; Institute of Health Center for Regenerative Therapies, Charité University Medicine, Berlin.<br /><searchLink fieldCode="AU" term="%22Thiele+H%22">Thiele H</searchLink>; 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DZHK Partner Site Lower Saxony, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Suling+A%22">Suling A</searchLink>; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Haeusler+KG%22">Haeusler KG</searchLink>; Department of Neurology, University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Endres+M%22">Endres M</searchLink>; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.; Department of Neurology, Charité University Medicine Berlin, Berlin.<br /><searchLink fieldCode="AU" term="%22Wegscheider+K%22">Wegscheider K</searchLink>; DZHK Partner Site Hamburg-Kiel-Lübeck, Hamburg, Germany.; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Boldt+LH%22">Boldt LH</searchLink>; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.; 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