Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation.
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| Title: | Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation. |
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| Authors: | Landmesser U; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Charité University Medicine Berlin, Berlin.; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.; Friede Springer Cardiovascular Prevention Center, Berlin., Skurk C; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Charité University Medicine Berlin, Berlin.; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin., Kirchhof P; Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.; DZHK Partner Site Hamburg-Kiel-Lübeck, Hamburg, Germany.; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom., Lewalter T; Department of Cardiology and Intensive Care Unit, Hospital Munich South, Peter Osypka Heart Center, Munich, Germany., Hartung J; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Charité University Medicine Berlin, Berlin.; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin., Rroku A; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Charité University Medicine Berlin, Berlin., Pieske B; Division of Cardiology, Department of Internal Medicine, University Medicine Rostock, Rostock, Germany., Brachmann J; Department of Cardiology, Klinikum Coburg, Coburg, Germany., Akin I; Department of Cardiology, Hemostaseology, and Medical Intensive Care, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Jacobshagen C; Department of Cardiology, Intensive Care Medicine, and Angiology, Vincentius-Diakonissen Hospital, Karlsruhe, Germany., Meder B; Precision Digital Health, Department of Internal Medicine III, Cardiology, University Heidelberg, Heidelberg, Germany.; DZHK Partner Site Heidelberg, Heidelberg, Germany., Zeiher A; Department of Medicine III, Goethe University, Frankfurt am Main, Germany.; DZHK Partner Site Rhein-Main, Frankfurt, Germany., Anker SD; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.; Institute of Health Center for Regenerative Therapies, Charité University Medicine, Berlin., Thiele H; Department of Internal Medicine-Cardiology, Heart Center at Leipzig University, Leipzig, Germany., Blankenberg S; Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.; DZHK Partner Site Hamburg-Kiel-Lübeck, Hamburg, Germany., Massberg S; Department of Medicine I, LMU University Hospital, Ludwig Maximillian University of Munich, Munich, Germany.; DZHK Partner Site Munich, Munich Heart Alliance, Munich, Germany., Schunkert H; DZHK Partner Site Munich, Munich Heart Alliance, Munich, Germany.; Department of Cardiovascular Diseases, German Heart Center, School of Medicine and Health, TUM University Hospital, Technical University of Munich, Munich, Germany., Frey N; Precision Digital Health, Department of Internal Medicine III, Cardiology, University Heidelberg, Heidelberg, Germany.; DZHK Partner Site Heidelberg, Heidelberg, Germany., Joost A; DZHK Partner Site Hamburg-Kiel-Lübeck, Hamburg, Germany.; University Heart Center Lübeck, Medical Clinic II (Cardiology-Angiology-Intensive Care Medicine), Lübeck, Germany., Bergmann M; Department of Cardiology, Asklepios Klinik Altona, Hamburg, Germany., von Bardeleben RS; Department of Cardiology, University Medical Center, Mainz, Germany., Friede T; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.; DZHK Partner Site Lower Saxony, Göttingen, Germany., Placzek M; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.; DZHK Partner Site Lower Saxony, Göttingen, Germany., Suling A; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Haeusler KG; Department of Neurology, University Hospital Ulm, Ulm, Germany., Endres M; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.; Department of Neurology, Charité University Medicine Berlin, Berlin., Wegscheider K; DZHK Partner Site Hamburg-Kiel-Lübeck, Hamburg, Germany.; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Boldt LH; German Center for Cardiovascular Research (DZHK) Partner Site Berlin, Berlin.; Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charité; Campus Virchow, Berlin., Eitel I; DZHK Partner Site Hamburg-Kiel-Lübeck, Hamburg, Germany.; University Heart Center Lübeck, Medical Clinic II (Cardiology-Angiology-Intensive Care Medicine), Lübeck, Germany. |
| Corporate Authors: | CLOSURE-AF Trial Investigators |
| Source: | The New England journal of medicine [N Engl J Med] 2026 Apr 02; Vol. 394 (13), pp. 1270-1280. Date of Electronic Publication: 2026 Mar 18. |
| Publication Type: | Clinical Trial, Phase IV; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
| Journal Info: | Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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