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Fluorescence polarization-based discovery of natural RORγ orthosteric inhibitors.

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Title: Fluorescence polarization-based discovery of natural RORγ orthosteric inhibitors.
Authors: Yu YC; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China., Huang N; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China., Zhao ZH; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China., Bao RF; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China., Xu F; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China., Xu ZQ; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China., Wu YC; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China., Leng XJ; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China., Ma XY; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China., Cao QQ; NCPC GeneTech Biotechnology Development Company Limited, High and New Technology Industries Development Zone, No.106 Tianshan South Street, Shijiazhuang, Hebei Province, China., Sun SL; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China., Zhong H; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: cpuzhonghui@126.com., Li NG; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China. Electronic address: linianguang@163.com.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 May 05; Vol. 309, pp. 118778. Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Fluorescence polarization-based discovery of natural RORγ orthosteric inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Yu+YC%22">Yu YC</searchLink>; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China.<br /><searchLink fieldCode="AU" term="%22Huang+N%22">Huang N</searchLink>; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China.<br /><searchLink fieldCode="AU" term="%22Zhao+ZH%22">Zhao ZH</searchLink>; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China.<br /><searchLink fieldCode="AU" term="%22Bao+RF%22">Bao RF</searchLink>; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.<br /><searchLink fieldCode="AU" term="%22Xu+F%22">Xu F</searchLink>; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China.<br /><searchLink fieldCode="AU" term="%22Xu+ZQ%22">Xu ZQ</searchLink>; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China.<br /><searchLink fieldCode="AU" term="%22Wu+YC%22">Wu YC</searchLink>; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China.<br /><searchLink fieldCode="AU" term="%22Leng+XJ%22">Leng XJ</searchLink>; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China.<br /><searchLink fieldCode="AU" term="%22Ma+XY%22">Ma XY</searchLink>; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China.<br /><searchLink fieldCode="AU" term="%22Cao+QQ%22">Cao QQ</searchLink>; NCPC GeneTech Biotechnology Development Company Limited, High and New Technology Industries Development Zone, No.106 Tianshan South Street, Shijiazhuang, Hebei Province, China.<br /><searchLink fieldCode="AU" term="%22Sun+SL%22">Sun SL</searchLink>; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China.<br /><searchLink fieldCode="AU" term="%22Zhong+H%22">Zhong H</searchLink>; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: cpuzhonghui@126.com.<br /><searchLink fieldCode="AU" term="%22Li+NG%22">Li NG</searchLink>; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, Jiangsu, 210023, China. Electronic address: linianguang@163.com.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 May 05; Vol. 309, pp. 118778. <i>Date of Electronic Publication: </i>2026 Mar 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ejmech.2026.118778
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        Text: English
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              Text: 2026 May 05
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