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Hepatocyte specific Rab27a knockout aggravates metabolic dysfunction associated fatty liver disease.

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Title: Hepatocyte specific Rab27a knockout aggravates metabolic dysfunction associated fatty liver disease.
Authors: Hu JY; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; Liver and non-liver Comorbidity Research Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China., Liao XY; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; Liver and non-liver Comorbidity Research Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China., Ran RZ; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China., Lu TT; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China; Liver and non-liver Comorbidity Research Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China., Lin Y; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China; Liver and non-liver Comorbidity Research Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China., Wang MW; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; Liver and non-liver Comorbidity Research Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China., Lin MJ; Academic Affairs Department, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, 410011, China; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, 410011, China. Electronic address: bruce1148@163.com., Liang X; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. Electronic address: xin.liang@ecust.edu.cn., Yang MQ; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China; Liver and non-liver Comorbidity Research Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China. Electronic address: andyymq@foxmail.com.
Source: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2026 Jun; Vol. 1872 (5), pp. 168223. Date of Electronic Publication: 2026 Mar 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-260X (Electronic) Linking ISSN: 09254439 NLM ISO Abbreviation: Biochim Biophys Acta Mol Basis Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hepatocyte specific Rab27a knockout aggravates metabolic dysfunction associated fatty liver disease.
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  Data: <searchLink fieldCode="AU" term="%22Hu+JY%22">Hu JY</searchLink>; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; Liver and non-liver Comorbidity Research Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.<br /><searchLink fieldCode="AU" term="%22Liao+XY%22">Liao XY</searchLink>; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; Liver and non-liver Comorbidity Research Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.<br /><searchLink fieldCode="AU" term="%22Ran+RZ%22">Ran RZ</searchLink>; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.<br /><searchLink fieldCode="AU" term="%22Lu+TT%22">Lu TT</searchLink>; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China; Liver and non-liver Comorbidity Research Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.<br /><searchLink fieldCode="AU" term="%22Lin+Y%22">Lin Y</searchLink>; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China; Liver and non-liver Comorbidity Research Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.<br /><searchLink fieldCode="AU" term="%22Wang+MW%22">Wang MW</searchLink>; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; Liver and non-liver Comorbidity Research Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.<br /><searchLink fieldCode="AU" term="%22Lin+MJ%22">Lin MJ</searchLink>; Academic Affairs Department, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, 410011, China; Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, 410011, China. Electronic address: bruce1148@163.com.<br /><searchLink fieldCode="AU" term="%22Liang+X%22">Liang X</searchLink>; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. Electronic address: xin.liang@ecust.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yang+MQ%22">Yang MQ</searchLink>; Department of Hepatobiliary Surgery Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China; Liver and non-liver Comorbidity Research Center, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China. Electronic address: andyymq@foxmail.com.
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        Value: 10.1016/j.bbadis.2026.168223
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        Text: English
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        StartPage: 168223
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      – TitleFull: Hepatocyte specific Rab27a knockout aggravates metabolic dysfunction associated fatty liver disease.
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            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
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