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Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.

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Title: Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.
Authors: Le BV; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Vekariya U; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Toma MM; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Nieborowska-Skorska M; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Caron MC; CHU de Québec Research Centre (Oncology Division, Hôpital Enfant-Jesus) and Laval University Cancer Research Center, Québec City, QC G1V 4G2, Canada., Gozdecka M; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK., Haydar Z; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Walsh M; Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, PA, USA; Nuclear Dynamics and Cancer Program, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA., Ghosh J; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Vaughan-Williams E; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Podszywalow-Bartnicka P; Laboratory of Cytometry, Nencki Institute of Experimental Biology Polish Academy of Sciences, 02-093 Warsaw, Poland., Kukuyan AM; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Ziolkowska S; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Atkins J; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Hadzijusufovic E; Department for Companion Animals & Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Vienna 1210, Austria; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna 1090, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna 1990, Austria., Chandramouly G; Department of Biochemistry and Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA., Nejati R; Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA., Piwocka K; Laboratory of Cytometry, Nencki Institute of Experimental Biology Polish Academy of Sciences, 02-093 Warsaw, Poland., Pomerantz R; Department of Biochemistry and Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA., Vassiliou GS; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK., Huntly BJP; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK., Valent P; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna 1090, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna 1990, Austria., Wasik M; Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA., Bellacosa A; Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, PA, USA., Masson JY; CHU de Québec Research Centre (Oncology Division, Hôpital Enfant-Jesus) and Laval University Cancer Research Center, Québec City, QC G1V 4G2, Canada., Gupta GP; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Challen GA; Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Skorski T; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA; Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address: tskorski@temple.edu.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Mar 17; Vol. 7 (3), pp. 102687.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Le+BV%22">Le BV</searchLink>; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Vekariya+U%22">Vekariya U</searchLink>; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Toma+MM%22">Toma MM</searchLink>; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Nieborowska-Skorska+M%22">Nieborowska-Skorska M</searchLink>; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Caron+MC%22">Caron MC</searchLink>; CHU de Québec Research Centre (Oncology Division, Hôpital Enfant-Jesus) and Laval University Cancer Research Center, Québec City, QC G1V 4G2, Canada.<br /><searchLink fieldCode="AU" term="%22Gozdecka+M%22">Gozdecka M</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Haydar+Z%22">Haydar Z</searchLink>; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Walsh+M%22">Walsh M</searchLink>; Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, PA, USA; Nuclear Dynamics and Cancer Program, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.<br /><searchLink fieldCode="AU" term="%22Ghosh+J%22">Ghosh J</searchLink>; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Vaughan-Williams+E%22">Vaughan-Williams E</searchLink>; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Podszywalow-Bartnicka+P%22">Podszywalow-Bartnicka P</searchLink>; Laboratory of Cytometry, Nencki Institute of Experimental Biology Polish Academy of Sciences, 02-093 Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Kukuyan+AM%22">Kukuyan AM</searchLink>; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Ziolkowska+S%22">Ziolkowska S</searchLink>; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Atkins+J%22">Atkins J</searchLink>; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.<br /><searchLink fieldCode="AU" term="%22Hadzijusufovic+E%22">Hadzijusufovic E</searchLink>; Department for Companion Animals & Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Vienna 1210, Austria; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna 1090, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna 1990, Austria.<br /><searchLink fieldCode="AU" term="%22Chandramouly+G%22">Chandramouly G</searchLink>; Department of Biochemistry and Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.<br /><searchLink fieldCode="AU" term="%22Nejati+R%22">Nejati R</searchLink>; Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.<br /><searchLink fieldCode="AU" term="%22Piwocka+K%22">Piwocka K</searchLink>; Laboratory of Cytometry, Nencki Institute of Experimental Biology Polish Academy of Sciences, 02-093 Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Pomerantz+R%22">Pomerantz R</searchLink>; Department of Biochemistry and Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.<br /><searchLink fieldCode="AU" term="%22Vassiliou+GS%22">Vassiliou GS</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Huntly+BJP%22">Huntly BJP</searchLink>; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Valent+P%22">Valent P</searchLink>; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna 1090, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna 1990, Austria.<br /><searchLink fieldCode="AU" term="%22Wasik+M%22">Wasik M</searchLink>; Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.<br /><searchLink fieldCode="AU" term="%22Bellacosa+A%22">Bellacosa A</searchLink>; Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Masson+JY%22">Masson JY</searchLink>; CHU de Québec Research Centre (Oncology Division, Hôpital Enfant-Jesus) and Laval University Cancer Research Center, Québec City, QC G1V 4G2, Canada.<br /><searchLink fieldCode="AU" term="%22Gupta+GP%22">Gupta GP</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Challen+GA%22">Challen GA</searchLink>; Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Skorski+T%22">Skorski T</searchLink>; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA; Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address: tskorski@temple.edu.
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