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Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling.

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Title: Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling.
Authors: Okda HE; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States., Zhao P; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States., Hayes M; Department of Cellular and Systems Pharmacology, University of Florida College of Pharmacy, Gainesville, FL, 32610, United States; University of Florida Genetics Institute, University of Florida School of Medicine, Gainesville, FL, 32610, United States., Duvall C; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St. Louis, MO, 63110, United States., Quillin E; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States., Fang H; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St. Louis, MO, 63110, United States., Mohammed BM; Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, 63104, United States., Hegazy L; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St. Louis, MO, 63110, United States., Burris TP; Department of Cellular and Systems Pharmacology, University of Florida College of Pharmacy, Gainesville, FL, 32610, United States; University of Florida Genetics Institute, University of Florida School of Medicine, Gainesville, FL, 32610, United States., Elgendy B; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States. Electronic address: belgendy@wustl.edu.
Source: International journal of biological macromolecules [Int J Biol Macromol] 2026 Apr; Vol. 355, pp. 151450. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling.
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  Data: <searchLink fieldCode="AU" term="%22Okda+HE%22">Okda HE</searchLink>; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States.<br /><searchLink fieldCode="AU" term="%22Zhao+P%22">Zhao P</searchLink>; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States.<br /><searchLink fieldCode="AU" term="%22Hayes+M%22">Hayes M</searchLink>; Department of Cellular and Systems Pharmacology, University of Florida College of Pharmacy, Gainesville, FL, 32610, United States; University of Florida Genetics Institute, University of Florida School of Medicine, Gainesville, FL, 32610, United States.<br /><searchLink fieldCode="AU" term="%22Duvall+C%22">Duvall C</searchLink>; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St. Louis, MO, 63110, United States.<br /><searchLink fieldCode="AU" term="%22Quillin+E%22">Quillin E</searchLink>; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States.<br /><searchLink fieldCode="AU" term="%22Fang+H%22">Fang H</searchLink>; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St. Louis, MO, 63110, United States.<br /><searchLink fieldCode="AU" term="%22Mohammed+BM%22">Mohammed BM</searchLink>; Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, 63104, United States.<br /><searchLink fieldCode="AU" term="%22Hegazy+L%22">Hegazy L</searchLink>; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St. Louis, MO, 63110, United States.<br /><searchLink fieldCode="AU" term="%22Burris+TP%22">Burris TP</searchLink>; Department of Cellular and Systems Pharmacology, University of Florida College of Pharmacy, Gainesville, FL, 32610, United States; University of Florida Genetics Institute, University of Florida School of Medicine, Gainesville, FL, 32610, United States.<br /><searchLink fieldCode="AU" term="%22Elgendy+B%22">Elgendy B</searchLink>; Center for Clinical Pharmacology, Department of Anaesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, United States. Electronic address: belgendy@wustl.edu.
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  Data: <searchLink fieldCode="JN" term="%227909578%22">International journal of biological macromolecules</searchLink> [Int J Biol Macromol] 2026 Apr; Vol. 355, pp. 151450. <i>Date of Electronic Publication: </i>2026 Mar 16.
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              Text: 2026 Apr
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