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Loss of PRKACB facilitates metastasis of diffuse-type gastric cancer through RhoA signaling activation.

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Title: Loss of PRKACB facilitates metastasis of diffuse-type gastric cancer through RhoA signaling activation.
Authors: Sun J; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China., Zhao J; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of General Surgery, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China., Yang X; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China., Tian C; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China., Ji C; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China., Liu J; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China., Nomura S; Department of Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan., Ruan Y; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China. ryyfdu@126.com.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China. ryyfdu@126.com., Wang X; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China. wang.xuefei@zs-hospital.sh.cn.; Department of General Surgery, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China. wang.xuefei@zs-hospital.sh.cn.; Clinical Research Center for Precision Medicine of Abdominal Tumor of Fujian Province, Xiamen, Fujian, China. wang.xuefei@zs-hospital.sh.cn., Li H; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China. li.haojie@zs-hospital.sh.cn.; Department of General Surgery, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China. li.haojie@zs-hospital.sh.cn.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 18; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Loss of PRKACB facilitates metastasis of diffuse-type gastric cancer through RhoA signaling activation.
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  Data: <searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of General Surgery, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Tian+C%22">Tian C</searchLink>; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Ji+C%22">Ji C</searchLink>; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Nomura+S%22">Nomura S</searchLink>; Department of Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ruan+Y%22">Ruan Y</searchLink>; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China. ryyfdu@126.com.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China. ryyfdu@126.com.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China. wang.xuefei@zs-hospital.sh.cn.; Department of General Surgery, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China. wang.xuefei@zs-hospital.sh.cn.; Clinical Research Center for Precision Medicine of Abdominal Tumor of Fujian Province, Xiamen, Fujian, China. wang.xuefei@zs-hospital.sh.cn.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University; Cancer Center, Zhongshan Hospital, Fudan University; Gastric Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China. li.haojie@zs-hospital.sh.cn.; Department of General Surgery, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China. li.haojie@zs-hospital.sh.cn.
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              Text: 2026 Mar 18
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