Divergent white matter metabolic signature patterns indicate impending cognitive decline in aging and dementia.

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Title: Divergent white matter metabolic signature patterns indicate impending cognitive decline in aging and dementia.
Authors: Zhang W; Department of Radiology, Mayo Clinic, Rochester, MN, USA.; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China., Raghavan S; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Tian J; Department of Radiology, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA., Przybelski SA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Wiste HJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Fought AJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Senjem ML; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Schwarz CG; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Reid RI; Department of Radiology, Mayo Clinic, Rochester, MN, USA.; Department of Information Technology, Mayo Clinic, Rochester, MN, USA., Machulda MM; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Petersen RC; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Lowe VJ; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Vemuri P; Department of Radiology, Mayo Clinic, Rochester, MN, USA. vemuri.prashanthi@mayo.edu.
Corporate Authors: Alzheimer’s Disease Neuroimaging Initiative
Source: Nature communications [Nat Commun] 2026 Mar 19; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-70707-6