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FGFR signaling establishes spatial gradients of secretory cell identities along the airway proximal-distal axis.

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Title: FGFR signaling establishes spatial gradients of secretory cell identities along the airway proximal-distal axis.
Authors: Sountoulidis A; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden. alexandros.sountoulidis@su.se., Theelke J; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden., Liontos A; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden., Firsova AB; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden., Eliot O; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden., Koepke J; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany., Millar-Büchner P; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany., Mannerås-Holm L; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Björklund Å; Department of Life Sciences, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology, Göteborg, Sweden., Fysikopoulos A; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany., Kelm A; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden., Bouloukou E; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany., Gaengel K; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden., Bäckhed F; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Novo Nordisk Foundation Microbiome Health Initiative, National Food Institute, Technical University of Denmark, Lyngby, Denmark., Betsholtz C; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.; Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden., Seeger W; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany., Bellusci S; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany., Samakovlis C; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden. christos.samakovlis@su.se.; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany. christos.samakovlis@su.se.
Source: Nature communications [Nat Commun] 2026 Mar 18; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: FGFR signaling establishes spatial gradients of secretory cell identities along the airway proximal-distal axis.
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  Data: <searchLink fieldCode="AU" term="%22Sountoulidis+A%22">Sountoulidis A</searchLink>; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden. alexandros.sountoulidis@su.se.<br /><searchLink fieldCode="AU" term="%22Theelke+J%22">Theelke J</searchLink>; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Liontos+A%22">Liontos A</searchLink>; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Firsova+AB%22">Firsova AB</searchLink>; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Eliot+O%22">Eliot O</searchLink>; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Koepke+J%22">Koepke J</searchLink>; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Millar-Büchner+P%22">Millar-Büchner P</searchLink>; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Mannerås-Holm+L%22">Mannerås-Holm L</searchLink>; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Björklund+Å%22">Björklund Å</searchLink>; Department of Life Sciences, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology, Göteborg, Sweden.<br /><searchLink fieldCode="AU" term="%22Fysikopoulos+A%22">Fysikopoulos A</searchLink>; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Kelm+A%22">Kelm A</searchLink>; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bouloukou+E%22">Bouloukou E</searchLink>; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Gaengel+K%22">Gaengel K</searchLink>; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Bäckhed+F%22">Bäckhed F</searchLink>; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Novo Nordisk Foundation Microbiome Health Initiative, National Food Institute, Technical University of Denmark, Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Betsholtz+C%22">Betsholtz C</searchLink>; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.; Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden.<br /><searchLink fieldCode="AU" term="%22Seeger+W%22">Seeger W</searchLink>; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Bellusci+S%22">Bellusci S</searchLink>; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Samakovlis+C%22">Samakovlis C</searchLink>; Department of Molecular Biosciences, The Wenner-Gren Institute (MBW), Science for Life Laboratory, Stockholm University, Stockholm, Sweden. christos.samakovlis@su.se.; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Institute for Lung Health, Cardio-Pulmonary Institute (CPI), Giessen, Germany. christos.samakovlis@su.se.
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