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Catabolism of extracellular glutathione supplies cysteine to support tumours.

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Title: Catabolism of extracellular glutathione supplies cysteine to support tumours.
Authors: Hecht F; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA. fabio_hechtcastromedeiro@urmc.rochester.edu.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. fabio_hechtcastromedeiro@urmc.rochester.edu., Zocchi M; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Tuttle ET; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Ward NP; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Alimohammadi F; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Khan AA; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA., Gomes VC; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Smith B; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Twardowski JJ; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Mills BN; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.; Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA., Welle KA; University of Rochester Mass Spectrometry Resource Laboratory, Rochester, NY, USA., Ghaemmaghami S; University of Rochester Mass Spectrometry Resource Laboratory, Rochester, NY, USA.; Department of Biology, University of Rochester, Rochester, NY, USA., Zhou Z; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA., Gan Y; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA., Kang YP; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Cazarin J; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Soares ZG; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Ozgurses ME; Department of Physiology and Biophysics, University of Illinois College of Medicine, University of Illinois Cancer Center, Chicago, IL, USA., Zhao H; Department of Physiology and Biophysics, University of Illinois College of Medicine, University of Illinois Cancer Center, Chicago, IL, USA., Sheehan C; Ben May Department of Cancer Research, University of Chicago, Chicago, IL, USA., Cognet G; Ben May Department of Cancer Research, University of Chicago, Chicago, IL, USA., Munger LD; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Trivedi D; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Asantewaa G; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.; Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA., Blick-Nitko SK; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Zoeller JJ; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Chen Y; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA., Vasiliou V; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA., Turner BM; Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA., Mello SS; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Altman BJ; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA., Muir A; Ben May Department of Cancer Research, University of Chicago, Chicago, IL, USA., Coloff JL; Department of Physiology and Biophysics, University of Illinois College of Medicine, University of Illinois Cancer Center, Chicago, IL, USA., Munger J; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.; Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA., DeNicola GM; Department of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Harris IS; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA. isaac_harris@urmc.rochester.edu.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. isaac_harris@urmc.rochester.edu.; Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA. isaac_harris@urmc.rochester.edu.
Source: Nature [Nature] 2026 May; Vol. 653 (8115), pp. 933-941. Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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