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Treatment patterns, treat-to-target goals and clinical outcomes of patients with active lupus nephritis: real-world evidence from a multicentre cohort study.

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Title: Treatment patterns, treat-to-target goals and clinical outcomes of patients with active lupus nephritis: real-world evidence from a multicentre cohort study.
Authors: Kent J; Department of Nephrology, Monash Health, Clayton, Victoria, Australia.; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia., Xu X; GSK, Value, Evidence & Outcomes, Singapore, Singapore., Ramnarain A; Department of Nephrology, Monash Health, Clayton, Victoria, Australia.; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia., Louthrenoo W; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Golder V; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.; Rheumatology Department, Monash Health, Clayton, VIC, Australia., Hamijoyo L; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Padjadjaran University/Hasan Sadikin General Hospital, Bandung, Indonesia., Luo SF; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan., Wu YJ; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Chang Gung University, Keelung, Taiwan., Chen YH; Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan., Cho J; Rheumatology Division, Department of Medicine, National University Hospital, Singapore, Singapore., Lateef A; Department of Rheumatology, Division of Medicine, Woodlands Health, Singapore, Singapore., Chan S; Division of Rheumatology & Clinical Immunology, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Pokfulam, Hong Kong., Lau CS; Division of Rheumatology & Clinical Immunology, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Pokfulam, Hong Kong., Navarra S; Section of Rheumatology, University of Santo Tomas Hospital, Manila, Philippines., Zamora L; Section of Rheumatology, University of Santo Tomas Hospital, Manila, Philippines., Yao H; Department of Rheumatology and Immunology, People's Hospital, Peking University Health Science Center, Beijing, China., Sockalingam S; Department of Medicine, Faculty of Medicine, Universiti Malaya Medical Center, Kuala Lumpur, Malaysia., Basnayake B; Department of Nephrology, Teaching Hospital Kandy, Kandy, Sri Lanka., Hao Y; Department of Rheumatology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.; Rheumatology and Immunology Department, Peking University First Hospital, Beijing, China., Zhang Z; Rheumatology and Immunology Department, Peking University First Hospital, Beijing, China., Chan M; Department of Rheumatology, Tan Tock Seng Hospital, Allergy & Immunology, Singapore, Singapore., Xu C; Department of Rheumatology, Tan Tock Seng Hospital, Allergy & Immunology, Singapore, Singapore., Bae SC; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, and Hanyang University Institute for Rheumatology Research, Hanyang Institute of Bioscience and Biotechnology, Seoul, Korea., Katsumata Y; Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University, Tokyo, Japan., Kikuchi J; Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan., Kaneko Y; Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan., Takeuchi T; Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.; Department of Rheumatology and Applied/Clinical Immunology, Saitama Medical University, Saitama, Japan., Oon S; Department of Rheumatology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia., O'Neill S; Rheumatology Department, Liverpool Hospital, Liverpool, New South Wales, Australia.; Department of Rheumatology, Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia., Hassett G; Rheumatology Department, Liverpool Hospital, Liverpool, New South Wales, Australia., Goldblatt F; Department of Rheumatology, Flinders Medical Centre, Bedford Park, South Australia, Australia., Poh YJ; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore., Sapsford M; Health New Zealand Counties Manukau, Te Whatu Ora (Middlemore Hospital), Auckland, New Zealand., Tugnet N; Health New Zealand Auckland, Te Whatu Ora (Greenlane Clinical Centre, Auckland, New Zealand., Ng KPL; Health New Zealand Waitemata, Te Whatu Ora (North Shore Hospital), Auckland, New Zealand., Tee C; Department of Paediatrics, College of Medicine, University of the Philippines, Manila, Philippines., Tee M; Department of Paediatrics, College of Medicine, University of the Philippines, Manila, Philippines., Miyazaki Y; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Ohkubo N; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Tanaka Y; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.; Department of Molecular Targeted Therapeutics, University of Occupational and Environmental Health, Kitakyushu, Japan., Nikpour M; Department of Rheumatology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.; Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia., Hoi A; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.; Rheumatology Department, Monash Health, Clayton, VIC, Australia., Rojas AAN; Medical Affairs, GSK, Greater China & Intercontinental, Singapore, Singapore., Morand E; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.; Rheumatology Department, Monash Health, Clayton, VIC, Australia., Kandane-Rathnayake R; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia. rangi.kandane-rathnayake@monash.edu.
Source: Arthritis research & therapy [Arthritis Res Ther] 2026 Mar 18; Vol. 28 (1). Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101154438 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-6362 (Electronic) Linking ISSN: 14786354 NLM ISO Abbreviation: Arthritis Res Ther Subsets: MEDLINE
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  Data: Treatment patterns, treat-to-target goals and clinical outcomes of patients with active lupus nephritis: real-world evidence from a multicentre cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Kent+J%22">Kent J</searchLink>; Department of Nephrology, Monash Health, Clayton, Victoria, Australia.; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; GSK, Value, Evidence & Outcomes, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ramnarain+A%22">Ramnarain A</searchLink>; Department of Nephrology, Monash Health, Clayton, Victoria, Australia.; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Louthrenoo+W%22">Louthrenoo W</searchLink>; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.<br /><searchLink fieldCode="AU" term="%22Golder+V%22">Golder V</searchLink>; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.; Rheumatology Department, Monash Health, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hamijoyo+L%22">Hamijoyo L</searchLink>; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Padjadjaran University/Hasan Sadikin General Hospital, Bandung, Indonesia.<br /><searchLink fieldCode="AU" term="%22Luo+SF%22">Luo SF</searchLink>; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+YJ%22">Wu YJ</searchLink>; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Chang Gung University, Keelung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YH%22">Chen YH</searchLink>; Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cho+J%22">Cho J</searchLink>; Rheumatology Division, Department of Medicine, National University Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lateef+A%22">Lateef A</searchLink>; Department of Rheumatology, Division of Medicine, Woodlands Health, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+S%22">Chan S</searchLink>; Division of Rheumatology & Clinical Immunology, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Pokfulam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Lau+CS%22">Lau CS</searchLink>; Division of Rheumatology & Clinical Immunology, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Pokfulam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Navarra+S%22">Navarra S</searchLink>; Section of Rheumatology, University of Santo Tomas Hospital, Manila, Philippines.<br /><searchLink fieldCode="AU" term="%22Zamora+L%22">Zamora L</searchLink>; Section of Rheumatology, University of Santo Tomas Hospital, Manila, Philippines.<br /><searchLink fieldCode="AU" term="%22Yao+H%22">Yao H</searchLink>; Department of Rheumatology and Immunology, People's Hospital, Peking University Health Science Center, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Sockalingam+S%22">Sockalingam S</searchLink>; Department of Medicine, Faculty of Medicine, Universiti Malaya Medical Center, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Basnayake+B%22">Basnayake B</searchLink>; Department of Nephrology, Teaching Hospital Kandy, Kandy, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Hao+Y%22">Hao Y</searchLink>; Department of Rheumatology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.; Rheumatology and Immunology Department, Peking University First Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Rheumatology and Immunology Department, Peking University First Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chan+M%22">Chan M</searchLink>; Department of Rheumatology, Tan Tock Seng Hospital, Allergy & Immunology, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Department of Rheumatology, Tan Tock Seng Hospital, Allergy & Immunology, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Bae+SC%22">Bae SC</searchLink>; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, and Hanyang University Institute for Rheumatology Research, Hanyang Institute of Bioscience and Biotechnology, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Katsumata+Y%22">Katsumata Y</searchLink>; Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kikuchi+J%22">Kikuchi J</searchLink>; Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kaneko+Y%22">Kaneko Y</searchLink>; Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Takeuchi+T%22">Takeuchi T</searchLink>; Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.; Department of Rheumatology and Applied/Clinical Immunology, Saitama Medical University, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Oon+S%22">Oon S</searchLink>; Department of Rheumatology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22O'Neill+S%22">O'Neill S</searchLink>; Rheumatology Department, Liverpool Hospital, Liverpool, New South Wales, Australia.; Department of Rheumatology, Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Hassett+G%22">Hassett G</searchLink>; Rheumatology Department, Liverpool Hospital, Liverpool, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Goldblatt+F%22">Goldblatt F</searchLink>; Department of Rheumatology, Flinders Medical Centre, Bedford Park, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Poh+YJ%22">Poh YJ</searchLink>; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sapsford+M%22">Sapsford M</searchLink>; Health New Zealand Counties Manukau, Te Whatu Ora (Middlemore Hospital), Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Tugnet+N%22">Tugnet N</searchLink>; 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The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.; Department of Molecular Targeted Therapeutics, University of Occupational and Environmental Health, Kitakyushu, Japan.<br /><searchLink fieldCode="AU" term="%22Nikpour+M%22">Nikpour M</searchLink>; Department of Rheumatology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.; Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Hoi+A%22">Hoi A</searchLink>; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.; Rheumatology Department, Monash Health, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Rojas+AAN%22">Rojas AAN</searchLink>; Medical Affairs, GSK, Greater China & Intercontinental, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Morand+E%22">Morand E</searchLink>; Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.; 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