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Targeting Endothelial PDK4-EndoMT Feedback Loop Mitigates the Development of Thoracic Aortic Dissection in Mice.

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Title: Targeting Endothelial PDK4-EndoMT Feedback Loop Mitigates the Development of Thoracic Aortic Dissection in Mice.
Authors: Cao X; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China., Guo X; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Department of Vascular Surgery, Suqian First Hospital, China (X.G.)., Huang H; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China., Shen H; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China., Zhu J; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China., Gao Y; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China., Liu A; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China., Wang T; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China., Xue Z; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China., Tang C; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China., Ye L; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China., Shao L; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China., Yu Y; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China., Shen Z; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.
Source: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2026 May; Vol. 46 (5), pp. e324031. Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Targeting Endothelial PDK4-EndoMT Feedback Loop Mitigates the Development of Thoracic Aortic Dissection in Mice.
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  Data: <searchLink fieldCode="AU" term="%22Cao+X%22">Cao X</searchLink>; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Department of Vascular Surgery, Suqian First Hospital, China (X.G.).<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Shen+H%22">Shen H</searchLink>; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+A%22">Liu A</searchLink>; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Xue+Z%22">Xue Z</searchLink>; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Tang+C%22">Tang C</searchLink>; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Ye+L%22">Ye L</searchLink>; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Shao+L%22">Shao L</searchLink>; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.; Suzhou Medical College (X.C., X.G., H.H., H.S., J.Z., Y.G., A.L., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Shen+Z%22">Shen Z</searchLink>; Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital (X.C., X.G., H.H., H.S., J.Z., Y.G., T.W., Z.X., C.T., L.Y., L.S., Y.Y., Z.S.), Soochow University, Suzhou, China.
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        Value: 10.1161/ATVBAHA.125.324031
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              Text: 2026 May
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