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Use of ctDNA in Older Women with ER+ Breast Cancer to Facilitate Surgical De-escalation: A Prospective, Hybrid-Decentralized Trial with Correlative Studies.

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Title: Use of ctDNA in Older Women with ER+ Breast Cancer to Facilitate Surgical De-escalation: A Prospective, Hybrid-Decentralized Trial with Correlative Studies.
Authors: Carleton N; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Chang AC; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Chen F; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Dana Farber Cancer Institute, Boston, Massachusetts., Puhalla SL; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Foldi J; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Waltermire H; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Tin A; Natera, Inc. , San Carlos, California., Cowher MS; Division of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Lupinacci K; Division of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Diego EJ; Division of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Sabih Q; Division of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Johnson RR; Division of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Malhotra M; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Laubenthal A; Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Gorantla V; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Balic M; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Bhargava R; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Joy M; Translational Pathology Imaging Laboratory, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Freeman T; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Translational Pathology Imaging Laboratory, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; NSABP Foundation , Inc., NRG Oncology, Pittsburgh, Pennsylvania., Bridges C; Natera, Inc. , San Carlos, California., Kalashnikova E; Natera, Inc. , San Carlos, California., Rodriguez A; Natera, Inc. , San Carlos, California., Liu MC; Natera, Inc. , San Carlos, California., Oesterreich S; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Lee AV; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., McAuliffe PF; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Division of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2026 Jul 17; Vol. 32 (14), pp. 2957-2967.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Use of ctDNA in Older Women with ER+ Breast Cancer to Facilitate Surgical De-escalation: A Prospective, Hybrid-Decentralized Trial with Correlative Studies.
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  Data: <searchLink fieldCode="AU" term="%22Carleton+N%22">Carleton N</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Chang+AC%22">Chang AC</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Dana Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Puhalla+SL%22">Puhalla SL</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Foldi+J%22">Foldi J</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Waltermire+H%22">Waltermire H</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Tin+A%22">Tin A</searchLink>; Natera, Inc. , San Carlos, California.<br /><searchLink fieldCode="AU" term="%22Cowher+MS%22">Cowher MS</searchLink>; Division of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Lupinacci+K%22">Lupinacci K</searchLink>; Division of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Diego+EJ%22">Diego EJ</searchLink>; Division of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Sabih+Q%22">Sabih Q</searchLink>; Division of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Johnson+RR%22">Johnson RR</searchLink>; Division of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Malhotra+M%22">Malhotra M</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Laubenthal+A%22">Laubenthal A</searchLink>; Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Gorantla+V%22">Gorantla V</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Balic+M%22">Balic M</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Bhargava+R%22">Bhargava R</searchLink>; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Joy+M%22">Joy M</searchLink>; Translational Pathology Imaging Laboratory, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Freeman+T%22">Freeman T</searchLink>; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Translational Pathology Imaging Laboratory, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; NSABP Foundation , Inc., NRG Oncology, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Bridges+C%22">Bridges C</searchLink>; Natera, Inc. , San Carlos, California.<br /><searchLink fieldCode="AU" term="%22Kalashnikova+E%22">Kalashnikova E</searchLink>; Natera, Inc. , San Carlos, California.<br /><searchLink fieldCode="AU" term="%22Rodriguez+A%22">Rodriguez A</searchLink>; Natera, Inc. , San Carlos, California.<br /><searchLink fieldCode="AU" term="%22Liu+MC%22">Liu MC</searchLink>; Natera, Inc. , San Carlos, California.<br /><searchLink fieldCode="AU" term="%22Oesterreich+S%22">Oesterreich S</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Lee+AV%22">Lee AV</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22McAuliffe+PF%22">McAuliffe PF</searchLink>; Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Division of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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