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Proteomic analyses of human islets reveal potential markers of β cell dysfunction during prediabetes.

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Title: Proteomic analyses of human islets reveal potential markers of β cell dysfunction during prediabetes.
Authors: Cefalo CMA; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Unit of Endocrinology and Diabetology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Mezza T; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Unit of Endocrinology and Diabetology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Quero G; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Pancreatic Surgery Unit, Pancreatic Advanced Research Center (CRMPG)., Alfieri S; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Pancreatic Surgery Unit, Pancreatic Advanced Research Center (CRMPG)., Lucchetti D; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Multiplex Spatial Profiling Facility, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Colella F; Multiplex Spatial Profiling Facility, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Sgambato A; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Multiplex Spatial Profiling Facility, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Qian WJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA., Mari A; Institute of Neuroscience, National Research Council, Padova, Italy., Pontecorvi A; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Unit of Endocrinology and Diabetology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Giaccari A; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Unit of Endocrinology and Diabetology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Kulkarni RN; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts, USA.
Source: JCI insight [JCI Insight] 2026 Mar 19; Vol. 11 (9). Date of Electronic Publication: 2026 Mar 19 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Proteomic analyses of human islets reveal potential markers of β cell dysfunction during prediabetes.
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  Data: <searchLink fieldCode="AU" term="%22Cefalo+CMA%22">Cefalo CMA</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Unit of Endocrinology and Diabetology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mezza+T%22">Mezza T</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Unit of Endocrinology and Diabetology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Quero+G%22">Quero G</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Pancreatic Surgery Unit, Pancreatic Advanced Research Center (CRMPG).<br /><searchLink fieldCode="AU" term="%22Alfieri+S%22">Alfieri S</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Pancreatic Surgery Unit, Pancreatic Advanced Research Center (CRMPG).<br /><searchLink fieldCode="AU" term="%22Lucchetti+D%22">Lucchetti D</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Multiplex Spatial Profiling Facility, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Colella+F%22">Colella F</searchLink>; Multiplex Spatial Profiling Facility, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Sgambato+A%22">Sgambato A</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Multiplex Spatial Profiling Facility, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Qian+WJ%22">Qian WJ</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Mari+A%22">Mari A</searchLink>; Institute of Neuroscience, National Research Council, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Pontecorvi+A%22">Pontecorvi A</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Unit of Endocrinology and Diabetology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Giaccari+A%22">Giaccari A</searchLink>; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.; Unit of Endocrinology and Diabetology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Kulkarni+RN%22">Kulkarni RN</searchLink>; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts, USA.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2026 Mar 19; Vol. 11 (9). <i>Date of Electronic Publication: </i>2026 Mar 19 (<i>Print Publication: </i>2026).
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