Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism.

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Title: Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism.
Authors: Ayala DA; Department of Neuroscience & Experimental Therapeutics, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA.; Graduate Program in Medical Sciences, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA., Hall GM; Department of Neuroscience & Experimental Therapeutics, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA.; Texas A&M Institute for Neuroscience (TAMIN) , College Station, USA., Das D; Department of Neuroscience & Experimental Therapeutics, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA.; Graduate Program in Medical Sciences, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA., Tijerina E; Department of Neuroscience & Experimental Therapeutics, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA., Villagran LL; Department of Neuroscience & Experimental Therapeutics, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA., Khan Z; Department of Neuroscience & Experimental Therapeutics, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA., Paliwal D; Department of Neuroscience & Experimental Therapeutics, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA., Anand A; Department of Neuroscience & Experimental Therapeutics, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA., Rimer M; Department of Neuroscience & Experimental Therapeutics, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA.; Graduate Program in Medical Sciences, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA.; Texas A&M Institute for Neuroscience (TAMIN) , College Station, USA.; Graduate program in Genetics and Genomics , Texas A&M University Naresh K. Vashisht College of Medicine , 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA., Srinivasan R; Department of Neuroscience & Experimental Therapeutics, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA. rahul@tamu.edu.; Graduate Program in Medical Sciences, Texas A&M University Naresh K. Vashisht College of Medicine, 8447 John Sharp Pkwy, Bryan, TX, 77807-3260, USA. rahul@tamu.edu.; Texas A&M Institute for Neuroscience (TAMIN) , College Station, USA. rahul@tamu.edu.; Toxicology Graduate Program, College of Veterinary Medicine and Biomedical Sciences, College Station, TX, 77843, USA. rahul@tamu.edu.
Source: Cellular and molecular neurobiology [Cell Mol Neurobiol] 2026 Mar 19; Vol. 46 (1). Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 8200709 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6830 (Electronic) Linking ISSN: 02724340 NLM ISO Abbreviation: Cell Mol Neurobiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1573-6830
DOI:10.1007/s10571-026-01713-x