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Inhibition of USP7 Destabilizes the Noncanonical PRC1.1 Complex and Induces Neuroblastoma Differentiation.

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Title: Inhibition of USP7 Destabilizes the Noncanonical PRC1.1 Complex and Induces Neuroblastoma Differentiation.
Authors: Cmarik EA; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana.; Purdue Institute for Drug Discovery, West Lafayette, Indiana., Wahi A; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana., Chandekar SS; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana., Otchere SK; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana., Sturgis JE; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana., Salhotra S; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Basanthakumar AT; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Boyd NX; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana., DiGiovanni G; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Zhu H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts., Alexe G; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Schaefer DA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Liu X; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana.; Purdue Institute for Drug Discovery, West Lafayette, Indiana.; Department of Biochemistry, Purdue University, West Lafayette, Indiana., Marto JA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Buhrlage SJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts., Mabe NW; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana.; Purdue Institute for Drug Discovery, West Lafayette, Indiana.
Source: Molecular cancer research : MCR [Mol Cancer Res] 2026 Jul 02; Vol. 24 (7), pp. 555-575.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101150042 Publication Model: Print Cited Medium: Internet ISSN: 1557-3125 (Electronic) Linking ISSN: 15417786 NLM ISO Abbreviation: Mol Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibition of USP7 Destabilizes the Noncanonical PRC1.1 Complex and Induces Neuroblastoma Differentiation.
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  Data: <searchLink fieldCode="AU" term="%22Cmarik+EA%22">Cmarik EA</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana.; Purdue Institute for Drug Discovery, West Lafayette, Indiana.<br /><searchLink fieldCode="AU" term="%22Wahi+A%22">Wahi A</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana.<br /><searchLink fieldCode="AU" term="%22Chandekar+SS%22">Chandekar SS</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana.<br /><searchLink fieldCode="AU" term="%22Otchere+SK%22">Otchere SK</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana.<br /><searchLink fieldCode="AU" term="%22Sturgis+JE%22">Sturgis JE</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana.<br /><searchLink fieldCode="AU" term="%22Salhotra+S%22">Salhotra S</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Basanthakumar+AT%22">Basanthakumar AT</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Boyd+NX%22">Boyd NX</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.<br /><searchLink fieldCode="AU" term="%22DiGiovanni+G%22">DiGiovanni G</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Zhu+H%22">Zhu H</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Alexe+G%22">Alexe G</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Schaefer+DA%22">Schaefer DA</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana.; Purdue Institute for Drug Discovery, West Lafayette, Indiana.; Department of Biochemistry, Purdue University, West Lafayette, Indiana.<br /><searchLink fieldCode="AU" term="%22Marto+JA%22">Marto JA</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Buhrlage+SJ%22">Buhrlage SJ</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Stegmaier+K%22">Stegmaier K</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Mabe+NW%22">Mabe NW</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana.; Purdue Institute for Drug Discovery, West Lafayette, Indiana.
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              Text: 2026 Jul 02
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