Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial.
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| Title: | Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial. |
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| Authors: | Michels EHA; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands. Electronic address: e.h.michels@amsterdamumc.nl., Dequin PF; Department of Critical Care, University Hospital Center of Tours, Inserm UMR 1100, University of Tours, Tours, France., Butler JM; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., Guillon A; Department of Critical Care, University Hospital Center of Tours, Inserm UMR 1100, University of Tours, Tours, France., Evrard B; Inserm CIC 1435, Dupuytren University Hospital, Limoges, France; Medical-Surgical ICU, Dupuytren University Hospital, Limoges, France., Paling FP; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Reijnders TDY; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., Schuurman AR; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., van Engelen TSR; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., Brands X; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., Haak BW; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., Bos LDJ; Department of Intensive Care, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., Leroux C; Departments of Medicine and Anesthesia, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA., Giamarellos-Bourboulis EJ; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Stoker J; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., Prins JM; Department of Internal Medicine, Division of Infectious Disease, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., Faber DR; Department of Internal Medicine, BovenIJ Hospital, Amsterdam, Netherlands., Douma RA; Department of Internal Medicine, Flevo Hospital, Almere, Netherlands., Sweeney TE; Inflammatix, Sunnyvale, CA, USA., Malhotra-Kumar S; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium., Kluytmans JAJW; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Scicluna BP; Department of Applied Biomedical Science, University of Malta, Msida, Malta; Center for Molecular Medicine and Biobanking, University of Malta, Msida, Malta., Cremer OL; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Matthay M; Departments of Medicine and Anesthesia, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA., Calfee C; Departments of Medicine and Anesthesia, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA., Wiersinga WJ; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands; Department of Internal Medicine, Division of Infectious Disease, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., Peters-Sengers H; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands; Department of Epidemiology and Data Science, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., van der Poll T; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands; Department of Internal Medicine, Division of Infectious Disease, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands. |
| Source: | The Lancet. Respiratory medicine [Lancet Respir Med] 2026 Apr; Vol. 14 (4), pp. 327-340. Date of Electronic Publication: 2026 Mar 16. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 101605555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2619 (Electronic) Linking ISSN: 22132600 NLM ISO Abbreviation: Lancet Respir Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41856148 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Michels+EHA%22">Michels EHA</searchLink>; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands. Electronic address: e.h.michels@amsterdamumc.nl.<br /><searchLink fieldCode="AU" term="%22Dequin+PF%22">Dequin PF</searchLink>; Department of Critical Care, University Hospital Center of Tours, Inserm UMR 1100, University of Tours, Tours, France.<br /><searchLink fieldCode="AU" term="%22Butler+JM%22">Butler JM</searchLink>; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Guillon+A%22">Guillon A</searchLink>; Department of Critical Care, University Hospital Center of Tours, Inserm UMR 1100, University of Tours, Tours, France.<br /><searchLink fieldCode="AU" term="%22Evrard+B%22">Evrard B</searchLink>; Inserm CIC 1435, Dupuytren University Hospital, Limoges, France; Medical-Surgical ICU, Dupuytren University Hospital, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Paling+FP%22">Paling FP</searchLink>; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Reijnders+TDY%22">Reijnders TDY</searchLink>; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Schuurman+AR%22">Schuurman AR</searchLink>; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Engelen+TSR%22">van Engelen TSR</searchLink>; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Brands+X%22">Brands X</searchLink>; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Haak+BW%22">Haak BW</searchLink>; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Bos+LDJ%22">Bos LDJ</searchLink>; Department of Intensive Care, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Leroux+C%22">Leroux C</searchLink>; Departments of Medicine and Anesthesia, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Giamarellos-Bourboulis+EJ%22">Giamarellos-Bourboulis EJ</searchLink>; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Stoker+J%22">Stoker J</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Prins+JM%22">Prins JM</searchLink>; Department of Internal Medicine, Division of Infectious Disease, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Faber+DR%22">Faber DR</searchLink>; Department of Internal Medicine, BovenIJ Hospital, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Douma+RA%22">Douma RA</searchLink>; Department of Internal Medicine, Flevo Hospital, Almere, Netherlands.<br /><searchLink fieldCode="AU" term="%22Sweeney+TE%22">Sweeney TE</searchLink>; Inflammatix, Sunnyvale, CA, USA.<br /><searchLink fieldCode="AU" term="%22Malhotra-Kumar+S%22">Malhotra-Kumar S</searchLink>; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Kluytmans+JAJW%22">Kluytmans JAJW</searchLink>; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Scicluna+BP%22">Scicluna BP</searchLink>; Department of Applied Biomedical Science, University of Malta, Msida, Malta; Center for Molecular Medicine and Biobanking, University of Malta, Msida, Malta.<br /><searchLink fieldCode="AU" term="%22Cremer+OL%22">Cremer OL</searchLink>; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Matthay+M%22">Matthay M</searchLink>; Departments of Medicine and Anesthesia, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Calfee+C%22">Calfee C</searchLink>; Departments of Medicine and Anesthesia, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wiersinga+WJ%22">Wiersinga WJ</searchLink>; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands; Department of Internal Medicine, Division of Infectious Disease, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Peters-Sengers+H%22">Peters-Sengers H</searchLink>; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands; Department of Epidemiology and Data Science, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Poll+T%22">van der Poll T</searchLink>; Center for Infection and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands; Department of Internal Medicine, Division of Infectious Disease, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101605555%22">The Lancet. Respiratory medicine</searchLink> [Lancet Respir Med] 2026 Apr; Vol. 14 (4), pp. 327-340. <i>Date of Electronic Publication: </i>2026 Mar 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101605555 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-2619 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222132600%22">22132600 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Respir Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41856148 |
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