Screening of an FDA-approved drug library reveals MEK1/2 inhibitors block production of osteoarthritis mediators in activated human chondrocytes and synovial fibroblasts.
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| Title: | Screening of an FDA-approved drug library reveals MEK1/2 inhibitors block production of osteoarthritis mediators in activated human chondrocytes and synovial fibroblasts. |
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| Authors: | Coryell PR; Thurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: pcoryell@email.unc.edu., Fernandez Davila JG; Thurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: jfernan@email.unc.edu., Yanke AB; Department of Orthopedics, Rush University Medical Center, Chicago, IL, USA. Electronic address: adam.yanke@rushortho.com., Pearce KH; Center for Integrative Chemical and Biological Drug Discovery, University of North Carolina, Chapel Hill, NC, USA. Electronic address: khpearce@unc.edu., Loeser RF; Thurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: richard_loeser@med.unc.edu. |
| Source: | Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2026 Jun; Vol. 34 (6), pp. 806-818. Date of Electronic Publication: 2026 Mar 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: W.B. Saunders For The Osteoarthritis Research Society Country of Publication: England NLM ID: 9305697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9653 (Electronic) Linking ISSN: 10634584 NLM ISO Abbreviation: Osteoarthritis Cartilage Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1522-9653 |
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| DOI: | 10.1016/j.joca.2026.03.116 |
