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Screening of an FDA-approved drug library reveals MEK1/2 inhibitors block production of osteoarthritis mediators in activated human chondrocytes and synovial fibroblasts.

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Title: Screening of an FDA-approved drug library reveals MEK1/2 inhibitors block production of osteoarthritis mediators in activated human chondrocytes and synovial fibroblasts.
Authors: Coryell PR; Thurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: pcoryell@email.unc.edu., Fernandez Davila JG; Thurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: jfernan@email.unc.edu., Yanke AB; Department of Orthopedics, Rush University Medical Center, Chicago, IL, USA. Electronic address: adam.yanke@rushortho.com., Pearce KH; Center for Integrative Chemical and Biological Drug Discovery, University of North Carolina, Chapel Hill, NC, USA. Electronic address: khpearce@unc.edu., Loeser RF; Thurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: richard_loeser@med.unc.edu.
Source: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2026 Jun; Vol. 34 (6), pp. 806-818. Date of Electronic Publication: 2026 Mar 17.
Publication Type: Journal Article
Journal Info: Publisher: W.B. Saunders For The Osteoarthritis Research Society Country of Publication: England NLM ID: 9305697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9653 (Electronic) Linking ISSN: 10634584 NLM ISO Abbreviation: Osteoarthritis Cartilage Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Screening of an FDA-approved drug library reveals MEK1/2 inhibitors block production of osteoarthritis mediators in activated human chondrocytes and synovial fibroblasts.
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  Data: <searchLink fieldCode="AU" term="%22Coryell+PR%22">Coryell PR</searchLink>; Thurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: pcoryell@email.unc.edu.<br /><searchLink fieldCode="AU" term="%22Fernandez+Davila+JG%22">Fernandez Davila JG</searchLink>; Thurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: jfernan@email.unc.edu.<br /><searchLink fieldCode="AU" term="%22Yanke+AB%22">Yanke AB</searchLink>; Department of Orthopedics, Rush University Medical Center, Chicago, IL, USA. Electronic address: adam.yanke@rushortho.com.<br /><searchLink fieldCode="AU" term="%22Pearce+KH%22">Pearce KH</searchLink>; Center for Integrative Chemical and Biological Drug Discovery, University of North Carolina, Chapel Hill, NC, USA. Electronic address: khpearce@unc.edu.<br /><searchLink fieldCode="AU" term="%22Loeser+RF%22">Loeser RF</searchLink>; Thurston Arthritis Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: richard_loeser@med.unc.edu.
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  Data: <searchLink fieldCode="JN" term="%229305697%22">Osteoarthritis and cartilage</searchLink> [Osteoarthritis Cartilage] 2026 Jun; Vol. 34 (6), pp. 806-818. <i>Date of Electronic Publication: </i>2026 Mar 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22W%2EB%2E+Saunders+For+The+Osteoarthritis+Research+Society%22">W.B. Saunders For The Osteoarthritis Research Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9305697 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-9653 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210634584%22">10634584 </searchLink><i>NLM ISO Abbreviation: </i>Osteoarthritis Cartilage <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.joca.2026.03.116
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      – Code: eng
        Text: English
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      – TitleFull: Screening of an FDA-approved drug library reveals MEK1/2 inhibitors block production of osteoarthritis mediators in activated human chondrocytes and synovial fibroblasts.
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            NameFull: Coryell PR
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            – D: 01
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              Text: 2026 Jun
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              Value: 34
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              Value: 6
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            – TitleFull: Osteoarthritis and cartilage
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